• Publications
  • Influence
Papillomavirus E6 proteins.
The papillomaviruses are small DNA viruses that encode approximately eight genes, and require the host cell DNA replication machinery for their viral DNA replication. Thus papillomaviruses haveExpand
  • 271
  • 15
Regulation of telomerase by human papillomaviruses.
The E6 oncoprotein of human papillomaviruses (HPVs) induces telomerase activity in primary human epithelial cells. This activity is dependent on association of E6 with E6AP, a cellular ubiquitinExpand
  • 28
  • 3
An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes.
Activation of telomerase by human papillomavirus 16 (HPV16) E6 is a critical step for cell immortalization and transformation in human foreskin keratinocytes (HFKs). Multiple transcription factorsExpand
  • 23
  • 3
NFX1-123 and Poly(A) Binding Proteins Synergistically Augment Activation of Telomerase in Human Papillomavirus Type 16 E6-Expressing Cells
ABSTRACT Overcoming senescence signals in somatic cells is critical to cellular immortalization and carcinogenesis. High-risk human papillomavirus (HPV) can immortalize epithelial cells in cultureExpand
  • 69
  • 2
Missed opportunities for adolescent vaccination, 2006-2011.
OBJECTIVE To describe missed opportunities for meningococcal (MCV); tetanus, diphtheria, acellular pertussis (Tdap); and human papillomavirus (HPV) vaccination among adolescents. METHODSExpand
  • 50
  • 2
  • Open Access
NFX1-123 Increases hTERT Expression and Telomerase Activity Posttranscriptionally in Human Papillomavirus Type 16 E6 Keratinocytes
ABSTRACT High-risk human papillomavirus (HPV) E6 protein induces telomerase activity through transcriptional activation of hTERT, the catalytic subunit of telomerase. HPV type 16 (HPV16) E6 interactsExpand
  • 47
  • 2
NFX1 Plays a Role in Human Papillomavirus Type 16 E6 Activation of NFκB Activity
ABSTRACT High-risk human papillomavirus (HR HPV) requires differentiating epithelial cells to continue to divide in order to replicate the viral DNA. To achieve this, HPV perturbs several regulatoryExpand
  • 29
  • 1
NFX1-123 and Human Papillomavirus 16E6 Increase Notch Expression in Keratinocytes
ABSTRACT The high-risk human papillomavirus (HR HPV) E6 oncoprotein binds host cell proteins to dysregulate multiple regulatory pathways, including apoptosis and senescence. HR HPV16 E6 (16E6)Expand
  • 17
  • 1
  • Open Access
Human papillomavirus-associated cancers.
HPV is a small, nonenvelope, double stranded DNA virus of the Papillomaviridae family. Different HPVs are defi ned by their genotypes, with more than 100 described to date. HPV genotypes areExpand
  • 15
  • 1
  • Open Access
Activation of telomerase by HPVs.
Telomerase extends the ends of linear chromosomes, and its expression leads to cellular immortalization. In HPV-associated cancers, telomerase is universally detected, and this occurs by activationExpand
  • 7
  • 1