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Clinical Pharmacokinetics of Amiodarone
SummaryAmiodarone is an iodinated benzofuran derivative with recognised antiarrhythmic activity in man. As yet, its pharmacokinetic behaviour has not been satisfactorily characterised. Specific and… Expand
Tolerance to dobutamine after a 72 hour continuous infusion.
Abstract In this study we investigated the hemodynamic effects of dobutamine during short-term (2 hour) and long-term (four day) infusions. The heart rate, blood pressure, cardiac output, pulmonary… Expand
- R. Kates
- 1 February 1983
SummaryAn understanding of the pharmacokinetics of the calcium antagonists (slow-channel blocking drugs) is essential in order to design appropriate dosage regimens which will provide optimum… Expand
Biliary secretion of methotrexate in rats and its inhibition by probenecid.
The biliary secretion of methotrexate was investigated in rats under steady-state conditions. The transport system involved was saturable and displayed Michaelis-Menten-type kinetics. Values for the… Expand
Myocardial disposition and cardiac pharmacodynamics of verapamil in the dog.
The disposition of verapamil was studied in anesthetized open-chested dogs following administration of intravenous doses of 0.5 mg/kg. The plasma and myocardial verapamil concentration-time data were… Expand
Dobutamine pharmacokinetics in severe heart failure
Dobutamine pharmacokinetics was investigated in 7 patients with severe cardiac failure. Dobutamine was administered by a constant intravenous infusion at rates of 2 .5, 5.0, 7.5, and 10.0 µg/kg/min.… Expand
Metabolite cumulation during chronic propafenone dosing in arrhythmia
The cumulation of propafenone and two of its metabolites, 5‐hydroxypropafenone (5‐OHP) and N‐depropylpropafenone (NDPP), was examined in patients with frequent ventricular ectopy. After 2 weeks of… Expand
Evidence of a source of HIV type 1 within the central nervous system by ultraintensive sampling of cerebrospinal fluid and plasma.
- D. Haas, L. A. Clough, +14 authors B. Larder
- Biology, Medicine
- AIDS research and human retroviruses
- 10 October 2000
Defining the source of HIV-1 RNA in cerebrospinal fluid (CSF) will facilitate studies of treatment efficacy in the brain. Four antiretroviral drug-naive adults underwent two 48-hr ultraintensive CSF… Expand
Rapid high-pressure liquid chromatographic analysis of verapamil in blood and plasma.
A high-pressure liquid chromatographic assay procedure has been developed for verapamil in blood or plasma. A paired-ion solvent system with a reversed-phase column is employed. The procedure is… Expand
Verapamil disposition kinetics in chronic atrial fibrillation
- R. Kates, D. Keefe, J. Schwartz, S. Harapat, E. Kirsten, D. Harrison
- Clinical pharmacology and therapeutics
- 1 July 1981
Verapamil disposition was studied in 12 patients with chronic atrial fibrillation. After an intravenous bolus of 15 mg plasma concentration was determined and the data fit to a three‐compartment… Expand