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Clinical Pharmacokinetics of Amiodarone
SummaryAmiodarone is an iodinated benzofuran derivative with recognised antiarrhythmic activity in man. As yet, its pharmacokinetic behaviour has not been satisfactorily characterised. Specific andExpand
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Tolerance to dobutamine after a 72 hour continuous infusion.
Abstract In this study we investigated the hemodynamic effects of dobutamine during short-term (2 hour) and long-term (four day) infusions. The heart rate, blood pressure, cardiac output, pulmonaryExpand
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Calcium Antagonists
SummaryAn understanding of the pharmacokinetics of the calcium antagonists (slow-channel blocking drugs) is essential in order to design appropriate dosage regimens which will provide optimumExpand
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Biliary secretion of methotrexate in rats and its inhibition by probenecid.
  • R. Kates, T. Tozer
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1 September 1976
The biliary secretion of methotrexate was investigated in rats under steady-state conditions. The transport system involved was saturable and displayed Michaelis-Menten-type kinetics. Values for theExpand
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Myocardial disposition and cardiac pharmacodynamics of verapamil in the dog.
  • D. Keefe, R. Kates
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1982
The disposition of verapamil was studied in anesthetized open-chested dogs following administration of intravenous doses of 0.5 mg/kg. The plasma and myocardial verapamil concentration-time data wereExpand
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Dobutamine pharmacokinetics in severe heart failure
Dobutamine pharmacokinetics was investigated in 7 patients with severe cardiac failure. Dobutamine was administered by a constant intravenous infusion at rates of 2 .5, 5.0, 7.5, and 10.0 µg/kg/min.Expand
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Metabolite cumulation during chronic propafenone dosing in arrhythmia
The cumulation of propafenone and two of its metabolites, 5‐hydroxypropafenone (5‐OHP) and N‐depropylpropafenone (NDPP), was examined in patients with frequent ventricular ectopy. After 2 weeks ofExpand
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Evidence of a source of HIV type 1 within the central nervous system by ultraintensive sampling of cerebrospinal fluid and plasma.
Defining the source of HIV-1 RNA in cerebrospinal fluid (CSF) will facilitate studies of treatment efficacy in the brain. Four antiretroviral drug-naive adults underwent two 48-hr ultraintensive CSFExpand
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Rapid high-pressure liquid chromatographic analysis of verapamil in blood and plasma.
A high-pressure liquid chromatographic assay procedure has been developed for verapamil in blood or plasma. A paired-ion solvent system with a reversed-phase column is employed. The procedure isExpand
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Verapamil disposition kinetics in chronic atrial fibrillation
Verapamil disposition was studied in 12 patients with chronic atrial fibrillation. After an intravenous bolus of 15 mg plasma concentration was determined and the data fit to a three‐compartmentExpand
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