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Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity.
TLDR
Transport studies indicate that ATPase inhibition is an essential factor in the inhibitory mechanism of TPGS 1000 on cellular efflux pumps. Expand
Redox regulation of calcium ion channels: chemical and physiological aspects.
TLDR
Basic oxygen redox chemistry and methods of ROS detection with special emphasis on electron paramagnetic resonance (EPR) spectroscopy are reviewed and the present knowledge of redox regulation of Ca(2+) permeable ion channels such as voltage-gated Ca( 2+) channels, transient receptor potential (TRP) channels and Orai channels is focused on. Expand
Reconstitution and Characterization of the Polynuclear Iron-Sulfur Cluster in Pyruvate Formate-lyase-activating Enzyme
TLDR
The iron-sulfur cluster complement proved to be a prerequisite for effective binding of adenosylmethionine, which induces a characteristic shift of the EPR signal shape of the reduced enzyme form ([4Fe-4S]+) from axial to rhombic symmetry. Expand
Inverse regulation of melanoma growth and migration by Orai1/STIM2‐dependent calcium entry
TLDR
A dynamic model in which Orai1 and STIM2 inversely control melanoma growth and invasion is supported, which might prevent metastatic spread and render melanomas more susceptible to conventional therapy. Expand
Quercetinase QueD of Streptomyces sp. FLA, a monocupin dioxygenase with a preference for nickel and cobalt.
TLDR
On the basis of spectroscopic data, and considering the organic chemistry of flavonols, the nonredox role of the metal center in catalysis is discussed. Expand
Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.
TLDR
It is shown that pathological metabolic demand reverses the direction of the Nnt, consuming NADPH to support NADH and ATP production, but at the cost of NADPH-linked antioxidative capacity. Expand
Gene Cluster of Arthrobacter ilicis Rü61a Involved in the Degradation of Quinaldine to Anthranilate
TLDR
Qox is the first MCD-containing enzyme to be synthesized in a catalytically fully competent form by a heterologous host, and the catalytic properties and the UV-visible and EPR spectra of Qox purified from P. putida KT2440 pKP1 were essentially like those of wild-type Qox. Expand
Recognition of Bacterial Signal Peptides by Mammalian Formyl Peptide Receptors
TLDR
Bacterial signal peptides constitute a novel class of immune activators that are likely to contribute to mammalian immune defense against bacteria, and are discovered to be a vast family of natural FPR agonists. Expand
Flavonol 2,4-dioxygenase from Aspergillus niger DSM 821, a type 2 CuII-containing glycoprotein.
TLDR
The EPR spectrum of flavonol 2,4-dioxygenase (as isolated) showed the characteristic parameters of a nonblue type 2 CuII protein, and metal chelating agents strongly inhibited the enzymatic activity, but inactivation was not accompanied by loss of copper. Expand
Calcium binding and transport by coenzyme Q.
TLDR
It is shown that both CoQ10 and its analogue CoQ1, when exposed to CYP450 or alkaline media, undergo structural changes through a complex reaction pathway and form quinone structures with distinct properties, and electrochemically reduced forms of the new hydroxylated CoQs have higher antioxidative potential and are also able to bind and transport Ca(2+) across artificial biomimetic membranes. Expand
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