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Comparison of pharmacokinetic profiles of zolpidem buffered sublingual tablet and zolpidem oral immediate-release tablet: results from a single-center, single-dose, randomized, open-label crossover…
The initial rate of absorption was faster, and initial systemic exposure was greater, with ZST compared with oral IR, and systemic exposure of zolpidem was higher in females for both formulations. Expand
Pharmacokinetic properties of combination oxycodone plus racemic ibuprofen: two randomized, open-label, crossover studies in healthy adult volunteers.
- R. Kapil, A. Nolting, P. Roy, W. Fiske, I. Benedek, W. Abramowitz
- Clinical therapeutics
- 1 December 2004
The single-dose pharmacokinetic profiles of oxycodone and ibuprofen in these healthy volunteers were similar when these 2 drugs were given as monotherapy or in combination, suggesting bioequivalence. Expand
Oral Abuse Potential, Pharmacokinetics, and Safety of Once-Daily, Single-Entity, Extended-Release Hydrocodone (HYD) in Recreational Opioid Users
HYD demonstrated reduced oral abuse potential compared with hydrocodone solution in healthy adult, nondependent, recreational opioid users and safety was consistent with the known effects of opioid agonists. Expand
Pharmacokinetic Profile of Dexloxiglumide
In female patients with constipation-predominant IBS, clinical efficacy has been demonstrated following administration of dexloxiglumide 200mg three times daily and pharmacokinetics are dose-independent after both single and repeated oral three-times-daily doses in the dose range 100–400mg. Expand
Oral antiplatelet efficacy and specificity of a novel nonpeptide platelet GPIIb/IIIa receptor antagonist, DMP 802.
- S. Mousa, R. Olson, +15 authors P. Friedman
- Chemistry, Medicine
- Journal of cardiovascular pharmacology
- 1 August 1998
The alpha sulfonamide isoxazoline analog, DMP 802, is a novel oral antiplatelet agent with high affinity, relatively slow dissociation rate and specificity for human platelet GPIIb/IIIa receptors. Expand
Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration
It is confirmed that zolpidem clearance is lower in females than in males, and PD effects of zolPidem from ZST are greater in female subjects, due to a combination of higher plasma concentrations and greater intrinsic sensitivity. Expand
Once-weekly transdermal buprenorphine application results in sustained and consistent steady-state plasma levels.
- R. Kapil, A. Cipriano, +6 authors S. Harris
- Journal of pain and symptom management
- 1 July 2013
This was a randomized open-label study in healthy subjects to characterize the steady-state buprenorphine pharmacokinetics after the delivery of three consecutive seven-day BTDS applications, and BTDS 10 was safe and well tolerated. Expand
Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis.
- A. Garami, Y. Shimansky, +12 authors A. Romanovsky
- Medicine, Chemistry
- Pharmacology & therapeutics
- 9 January 2020
A mathematical model suggests that TRPV1 mediates both pH and thermal signals driving thermoregulation in humans, and in humans (but not in rats), TRpV1 is likely to serve as a thermosensor of the thermoreGulation system. Expand
Pharmacokinetics and metabolism of the cholecystokinin antagonist dexloxiglumide in male human subjects
- C. Webber, A. Roth, +9 authors L. Rovati
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in…
- 1 June 2003
LC-MS/MS of urine extracts showed that dexloxiglumide was metabolized by oxidation and conjugation, and the data were consistent with biliary excretion and perhaps some enterohepatic circulation of conjugates of Dexloxigumide and at least one of its metabolites. Expand
Pharmacokinetic Profile and Sustained 24-hour Analgesia of a Once-daily Hydrocodone Bitartrate Extended-release Tablet with Abuse-deterrent Properties.
Once-daily HYD exhibits linear, dose-proportional PK properties and is associated with a lower variability in plasma hydrocodone concentrations when compared with an immediate-release hydrocODone combination product. Expand