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First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288
TLDR
The trial demonstrates that a type I PAM can be safely administered to humans and that it has potential positive neurocognitive effects in central nervous system (CNS) disorders.
Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid
TLDR
UCI-50027 is an orally active neuroactive steroid with pharmacological activity consistent with a gamma-aminobutyric acid(A) receptor PAM that has an improved separation between anticonvulsant/anxiolytic and rotarod effects, potent activity as an anticonVulsant and anxIOlytic when compared to ganaxolone.
KINETIC STUDIES ON ANTHRALIN PHOTOOXIDATION
TLDR
The rate of deactivation of 1O2 increases at higher pH, demonstrating that the trihydroxy‐anthracene anion is the reactive species.
Sensitizer-substrate interactions in the 9,10-dicyanoanthracene-sensitized photooxygenation of trans-stilbene
The quantum yield of singlet oxygen ( 1 O 2 ) production from 9,10-dicyanoanthracene (DCA) in the presence of trans-stilbene (TS) was determined by measurement of its 1268-nm emission.
A simple method for extending the range of pseudo-order kinetic measurements
Data are presented demonstrating the validity of a new method of measuring pseudo-order rate constants, based on an iterative computational procedure long in use for kinetic conditions where the
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