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Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery
This review appraises the high degree of neurological and behavioural resemblance of zebrafish with humans and further elaborate on the use of recent real-time imaging techniques to obtain vital insights into the neurodegeneration that occurs in AD. Expand
Antimicrobial silver nanoparticle induces organ deformities in the developing Zebrafish (Danio rerio) embryos
Results shows silver nanoparticles dis-rupts the normal organogenesis during development and further detailed studies are needed to prove silver nanopartcles are an antimicrobial agent for use in humans. Expand
In vivo safety evaluation of antibacterial silver chloride nanoparticles from Streptomyces exfoliatus ICN25 in zebrafish embryos.
The properties of this biosynthesized nanoparticle suggest a path towards developing antibiotic nanoparticles that are likely to avoid development of multidrug resistance. Expand
β-lactamase inhibitory potential of kalafungin from marine Streptomyces in Staphylococcus aureus infected zebrafish.
It is suggested that kalafungin may useful for synergic antibacterial therapy with β- lactam drugs to overcome β-lactamase-based resistance of any bacterial pathogens. Expand
ELISA based quantification of Pax6 expression in the developing Zebrafish embryos
A reliable and sensitive assay for the spatiotemporal expression, quantification and detection of Pax6 is not available so far in zebrafish as a developmental model, hence the objective of this work is to develop quantitative assay inZebrafish embryos. Expand
Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19
Compound 1 exhibited potent activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, Mycobacterium smegmatis, and Micrococcus luteus, as well as cytotoxicity against A549 human lung carcinoma cells with an IC50 value of 6 nM. Expand
Cynodon dactylon and Sida acuta extracts impact on the function of the cardiovascular system in zebrafish embryos
An assay that can measure changes in cardiac function in response to herbal small molecules and determine the cardiogenic effects by microvideography is developed. Expand
Development of biocompatible nanogel for sustained drug release by overcoming the blood brain barrier in zebrafish model
Abstract A potential delivery system has to be fabricated for crossing the blood–brain barrier (BBB) to reach the brain fluid for effective delivery of drugs for any neurological disorders. TheExpand
Production of a compound against methicillin resistant Staphylococcus aureus (MRSA) from Streptomyces rubrolavendulae ICN3 & its evaluation in zebrafish embryos
The results suggested that the compound was potent with less toxic effects in zebrafish embryonic model system for MRSA infection and may lead to a novel drug candidate for drug resistant Staphylococcus aureus. Expand
Screening of herbal extracts influencing hematopoiesis and their chemical genetic effects in embryonic zebrafish
This in vivo based screening of Hematopoiesis is an inexpensive assay to screen herbal compounds and found that S. trilobatum extract influenced embryonic HSC in zebrafish, which could be a therapeutic for blood related disorders. Expand