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The basics of epithelial-mesenchymal transition.
The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. However, emergingExpand
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  • Open Access
Fibroblasts in cancer
Tumours are known as wounds that do not heal — this implies that cells that are involved in angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a prominent roleExpand
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Epithelial-mesenchymal transition and its implications for fibrosis.
Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and whileExpand
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The epithelial–mesenchymal transition: new insights in signaling, development, and disease
The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. Current interest in this process, which isExpand
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The biology and function of fibroblasts in cancer
  • R. Kalluri
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 September 2016
Among all cells, fibroblasts could be considered the cockroaches of the human body. They survive severe stress that is usually lethal to all other cells, and they are the only normal cell type thatExpand
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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
tl;dr
We revise and renew the “MISEV2014” guidelines for studies of extracellular vesicles based on evolution of the collective knowledge in the last four years. Expand
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  • Open Access
Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which isExpand
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  • Open Access
Angiogenesis: Basement membranes: structure, assembly and role in tumour angiogenesis
  • R. Kalluri
  • Chemistry, Biology
  • Nature Reviews Cancer
  • 1 June 2003
In recent years, the basement membrane (BM) — a specialized form of extracellular matrix (ECM) — has been recognized as an important regulator of cell behaviour, rather than just a structural featureExpand
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BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury
Bone morphogenic protein (BMP)-7 is a 35-kDa homodimeric protein and a member of the transforming growth factor (TGF)-β superfamily. BMP-7 expression is highest in the kidney, and its geneticExpand
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TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of theExpand
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  • Open Access