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Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
The bovine carrier structure, together with earlier biochemical results, suggests that transport substrates bind to the bottom of the cavity and that translocation results from a transient transition from a ‘pit’ to a ’channel’ conformation.
Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing.
The crystal structure of the carbohydrate-recognition domain of a rat mannose-binding protein, determined as the holmium-substituted complex by multiwavelength anomalous dispersion (MAD) phasing, reveals an unusual fold consisting of two distinct regions, one of which contains extensive nonregular secondary structure stabilized by two Holmium ions.
Structure of the bacteriophage T4 long tail fiber receptor-binding tip
The crystal structure of the receptor-binding tip of the bacteriophage T4 long tail fiber is presented, which reveals a previously unknown beta-structured fibrous fold, provides insights into the remarkable stability of the fiber, and suggests a framework for mutations to expand or modulate receptor- binding specificity.
Structural and functional studies of FkpA from Escherichia coli, a cis/trans peptidyl-prolyl isomerase with chaperone activity.
Results suggest that the chaperone and catalytic activities reside in the N and C-terminal domains of the dimeric molecule, respectively, which could effectively adapt these two independent folding functions of FkpA to polypeptide substrates.
The structural bases of the processive degradation of iota-carrageenan, a main cell wall polysaccharide of red algae.
From an open conformation which allows for the initial endo-attack of iota-carrageenan chains, the enzyme switches to a closed-tunnel form, consistent with its highly processive character, as seen from the electron-microscopy analysis of the degradation of iotian fibers.
Crystal structure of CbpF, a bifunctional choline‐binding protein and autolysis regulator from Streptococcus pneumoniae
The three‐dimensional structure of choline‐binding protein F (CbpF), one of the most abundant proteins in the pneumococcal cell wall, has been solved in complex with choline, showing a new modular structure composed both of consensus and non‐consensus ch Caroline‐binding repeats.
Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril.
The structures of the Zn-beta-lactamase from Fluoribacter gormanii (FEZ-1) in the native and in the complex form are reported here.
Gd-HPDO3A, a complex to obtain high-phasing-power heavy-atom derivatives for SAD and MAD experiments: results with tetragonal hen egg-white lysozyme.
The exceptional quality of the SAD electron-density map suggests that single-wavelength anomalous scattering with the Gd-HPDO3A complex may be sufficient to solve protein structures of high molecular weight by synchrotron-radiation experiments, if not by laboratory experiments.
High-pressure protein crystallography (HPPX): instrumentation, methodology and results on lysozyme crystals.
A new set-up and associated methodology for the collection of angle-dispersive diffraction data from protein crystals submitted to high hydrostastic pressure have been developed on beamline ID30 at