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Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
TLDR
It is suggested that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory. Expand
Control of endodermal endocrine development by Hes-1
TLDR
It is shown that mice deficient in Hes1 (encoding Hes-1) display severe pancreatic hypoplasia caused by depletion of pancreatic epithelial precursors due to accelerated differentiation of post-mitotic endocrine cells expressing glucagon, and upregulation of several bHLH components is associated with precocious and excessive differentiation of multiple endocrine cell types in the developing stomach and gut, showing that Hes- 1 operates as a general negative regulator of endodermal endocrine differentiation. Expand
Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation
TLDR
It is demonstrated that Hes1 and Hes5 are essential Notch effectors in regulation of mammalian neuronal differentiation in neural precursor cells prepared from wild‐type, Hes1‐null, Hes5‐null and Hes1-Hes5 double‐null mouse embryos. Expand
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split.
TLDR
The results suggest that HES-1 may play an important role in mammalian development by negatively acting on the two different sequences while Hes-3 acts as a repressor in a specific type of neurons. Expand
Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation
TLDR
It is reported that in activation of Hes1 and Hes5, known Notch effectors, and additional inactivation of Hes3 extensively accelerate cell differentiation and cause a wide range of defects in brain formation. Expand
Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects.
TLDR
Results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis. Expand
Roles of bHLH genes in neural stem cell differentiation.
TLDR
The activator-type and repressor-type bHLH genes regulate each other, allowing only subsets of cells to undergo differentiation while keeping others to stay neural stem cells. Expand
Oscillatory Expression of the bHLH Factor Hes1 Regulated by a Negative Feedback Loop
TLDR
It is shown that serum treatment of cultured cells induces cyclic expression of both mRNA and protein of the Notch effector Hes1, a basic helix-loop-helix (bHLH) factor, with 2-hour periodicity, which may regulate timing in many biological systems. Expand
A Mammalian Helix-Loop-Helix Factor Structurally Related to the Product of Drosophila Proneural Gene atonal Is a Positive Transcriptional Regulator Expressed in the Developing Nervous System(*)
TLDR
The results suggest that MATH-1 may be a target of HES-1 and play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription. Expand
The Hes gene family: repressors and oscillators that orchestrate embryogenesis
TLDR
This primer describes the pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis. Expand
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