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Mechanism of action of dipyridamole.
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The influence of renin on the intrarenal distribution of blood flow and autoregulation.
The influence of the renin-angiotensin system on renal autoregulation and intrarenal distribution of blood flow was studied in 10 dogs. Using a femoral-renal bypass, total renal blood flow and perfusi
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[Pharmacological properties of a new coronary dilator substance 2, 6-bis(diethanolamino)-4, 8-dipiperidino-pyrimido[5,4-d]pyrimidine].
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Absorption and activity of 2,6-bis-(diethanolamino)-4,8-dipiperidino-pyrimido-(5,4-d) pyrimidine (RA8) following enteric administration.
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Effects of AR-L 115 BS, a new cardiotonic compound, on cardiac contractility, heart rate and blood pressure in anaesthetized and conscious animals.
TLDR
Investigation of the basal values of cardiac contractility and the efficacy of i.v. administered AR-L 115 BS in dogs pretreated with 10 mg/kg/day orally for 6 and 12 months indicated that the compound did not accumulate and that no tolerance to the drug developed.
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Cardiovascular actions of 5,6-dimethoxy-2-(3-[(alpha-(3,4-dimethoxy) phenylethyl)-methylamino] propyl) phthalimidine (AQ-A 39), a specific bradycardic agent.
TLDR
A comparison of the cardiovascular actions of AQ-A 39 to those of the chemically related Ca2+-antagonist verapamil in anaesthetized cats revealed that AQ- a 39 reduced heart rate more that arterial blood pressure of left ventricular dpldtmax, whereas verap amil was more active in decreasing blood pressure and myocardial contractility that in reducing heart rate.
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Action of AR-L 115 BS on myocardial oxygen consumption, cardiac performance and vascular resistance and capacitance.
TLDR
Doses between 0.5 and 5.0 mg/kg i.v. reduced peripheral resistance by a direct vasodilating activity and increased venous capacity and Stroke volume and cardiac output were only slightly influenced by the drug.
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Effect of dipyridamole on blood platelets in pharmacological experiments.
TLDR
In in vivo models a good and long lasting inhibiting effect on primary haemostasis was seen in mice and an antithrombotic effect was achieved in a thrombus formation test in rats.
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Pharmacologic study of endobenzyline bromide, a new cholinergic blocking agent.
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Stimulation of sympathetic cardiovascular centres by RA 642, a new pyrimido-pyrimidine derivative
TLDR
RA 642 increased sympathetic and, following clonidine treatment, decreased vagal reflex activity, and stimulated the respiration by a central action, and had no convulsant action.
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