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Sonic Hedgehog and Notch Signaling Can Cooperate to Regulate Neurogenic Divisions of Neocortical Progenitors
Background Hedgehog (Hh) signaling is crucial for the generation and maintenance of both embryonic and adult stem cells, thereby regulating development and tissue homeostasis. In the developing…
Regulated Expression of PTPRJ/CD148 and an Antisense Long Noncoding RNA in Macrophages by Proinflammatory Stimuli
PTPRJ/CD148 is a tyrosine phosphatase that has tumour suppressor-like activity. Quantitative PCR of various cells and tissues revealed that it is preferentially expressed in macrophage-enriched…
Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma
Hedgehog-dependent medulloblastoma were not blocked by loss of RBP-J, indicating that canonical Notch signaling is not required for tumor initiation and growth in this model.
CD148/DEP-1 association with areas of cytoskeletal organisation in macrophages.
Expression and Function of the Protein Tyrosine Phosphatase Receptor J (PTPRJ) in Normal Mammary Epithelial Cells and Breast Tumors
PTPRJ mRNA is expressed in normal breast tissue and reduced in corresponding tumors, indicating that PTPRJ may regulate differentiation of normal mammary epithelia and that dysregulation of protein localisation may be associated with tumorigenesis.
Differential expression of CD148 on leukocyte subsets in inflammatory arthritis
CD148 is upregulated in macrophages and T cells in human RA samples, and its activity is enhanced by treatment with tumour necrosis factor alpha (TNFα), and reduced by synovial fluid or oxidising conditions.
Functional Characterisation of the role of Protein Tyrosine Phosphatase CD148 in Macrophages
- R. K. Dave
The functional characterisation of the receptor protein tyrosine phosphatase CD148 in macrophages is characterised and consistent with the hypothesis that CD148 is a regulator of macrophage activity and inflammation.