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Distribution of methylone in four postmortem cases.
TLDR
Analysis of several tissue samples shows that methylone does not sequester in a particular tissue type after death, and two different extraction methods, as well as analysis of derivatized and underivatized methylone, show that the drug is suitable for analysis in either method. Expand
Elimination of cocaine and metabolites in plasma, saliva, and urine following repeated oral administration to human volunteers.
TLDR
Cocaine accumulates in the body with chronic use resulting in a prolonged terminal elimination phase for cocaine and metabolites, which greatly exceeded previous estimates from studies of acute cocaine administration. Expand
Distribution of venlafaxine in three postmortem cases.
Venlafaxine (V) is a second-generation antidepressant approved for use in the United States in 1993. It is a derivative of phenethylamine and is structurally unrelated to first- and otherExpand
Effect of repeated cocaine administration on detection times in oral fluid and urine.
TLDR
It is concluded that the short detection times observed in single-dose studies underestimate the utility of oral fluid for detection of cocaine abuse in realistic settings. Expand
Attenuation of cocaine-induced locomotor activity by butyrylcholinesterase.
TLDR
It is suggested that systemic administration of BChE can increase the metabolism of cocaine sufficiently to alter a behavioral effect of cocaine and thus should be investigated as a potential treatment for cocaine abuse. Expand
Effects of delivery rate and non-contingent infusion of cocaine on cocaine self-administration in rhesus monkeys
TLDR
It is suggested that a low-dose, slow-delivery treatment with cocaine might prime or reinstate drug seeking rather than decrease it. Expand
Cocaine and metabolite concentrations in plasma during repeated oral administration: development of a human laboratory model of chronic cocaine use.
TLDR
It is demonstrated that chronic oral dosing of cocaine produced dose-related increases in plasma cocaine concentration, and this model could be useful for studying the effects of chronic cocaine use in human subjects. Expand
Forensic drug testing for opiates. VII. Urinary excretion profile of intranasal (snorted) heroin.
TLDR
Overall, intranasal administration of heroin produced a similar profile of excretion of heroin metabolites to intramuscular administration. Expand
Plasma butyrylcholinesterase activity and cocaine half-life differ significantly in rhesus and squirrel monkeys.
TLDR
The results indicate that BChE level can vary between species of non-human primates, a factor that should be taken into account when studying drugs such as cocaine which are metabolized by B ChE. Expand
Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in rats.
TLDR
It is suggested that butyrylcholinesterase treatment may have benefits in enhancing cocaine metabolism and in increasing levels of ecgonine methylester, which may have a protective action against cocaine. Expand
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