• Publications
  • Influence
Anti-inflammatory activity of para-substituted N-benzenesulfonyl derivatives of anthranilic acid.
Several para-substituted N-benzenesulfonyl derivatives of anthranilic acid were prepared and evaluated for anti-inflammatory activity using erythrocyte membrane stabilization and carrageenin-inducedExpand
  • 24
  • 1
Synthesis and biological activity of trans(+-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogues: a new class of potassium channel opener.
The synthesis and biological activity of trans-(+-)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamid+ ++ e 1-oxide (8a, RP 49356) and analogues is reported. These compounds constitute a newExpand
  • 31
RP 73163: A bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor
RP 73163 5 the major metabolite of the ACAT inhibitor RP 76076 3 retains ACAT activity. This alkylsulphinyl-4,5-diphenyl-1H-imidazole has higher systemic bioavailability than the parent thioether,Expand
  • 13
STRUCTURE AND PROPERTIES OF HYDROXYL RADICAL MODIFIED NUCLEIC ACID COMPONENTS. II. 8-OXO-ADENINE AND 8-OXO-2'-DEOXY-ADENOSINE
Abstract The tautomerism of the 8-oxo-adenine (8-oxo-A) and 8-oxo-2′-deoxy-adenosine (8-oxo-dA) was analysed on the basis of semiempirical, SCF ab initio and DFT density functional quantum chemistryExpand
  • 7
Oxygenation of a carbinol carbon in the pyrimidine deoxyribonucleoside 2'-hydroxylase reaction.
Abstract 1. 1. The pyrimidine deoxyribonucleoside 2'-hydroxylase (EC 1.14.11.3) reaction of Neurospora crassa was studied with uracil-β- d -arabinofuranoside (AraU) as the nucleoside substrate. 2. 2.Expand