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Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group
- C. Vitali, S. Bombardieri, M. Weisman
- Psychology, MedicineAnnals of the rheumatic diseases
- 1 June 2002
These classification criteria for Sjögren's syndrome have been re-examined by consensus group members, who have introduced some modifications, more clearly defined the rules for classifying patients with primary or secondary SS, and provided more precise exclusion criteria.
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
It is shown that one intronic SNP in PDCD1 is associated with development of SLE in Europeans, and this SNP alters a binding site for the runt-related transcription factor 1 (RUNX1) located in an intronic enhancer, suggesting a mechanism through which it can contribute to the development ofSLE in humans.
EuropeanStudy Group on Classification Criteria for Sjögren's Syndrome. Classificationcriteria for Sjögren's syndrome: a revised version of the European criteriaproposed by the American-European…
Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome.
The data suggest that the ectopic secondary lymphoid follicles of patients with Sjögren's syndrome contain all elements needed for driving the autoimmune response and underscore a key role for the target organ in recruitment of inflammatory cells and propagation of the disease process.
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome
The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others.
Several types of autoantibodies have been suggested to contribute to the pathogenesis of SS, however, how the tolerance to these structures is broken down is unknown at present.
Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors
- R. Omdal, K. Brokstad, K. Waterloo, W. Koldingsnes, R. Jonsson, S. Mellgren
- Psychology, BiologyEuropean journal of neurology
- 1 May 2005
Findings in several domains indicate an association between anti‐NR2 antibodies and depressed mood in addition to decreased short‐time memory and learning in patients with SLE.
Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)
It is shown that infection with viable periodontal pathogen Porphyromonas gingivalis strain W83 exacerbated collagen-induced arthritis in a mouse model, as manifested by earlier onset, accelerated progression and enhanced severity of the disease, including significantly increased bone and cartilage destruction.
Knowledge of SjS has progressed substantially, but this disease is still characterized by sicca symptoms, the systemic involvement of disease, lymphocytic infiltration to exocrine glands, the presence of anti-Ro/SSA and anti-La/SSB autoantibodies and the increased risk of lymphoma in patients with SJS.
The Complex Role of Vitamin D in Autoimmune Diseases
- P. Szodoray, B. Nakken, E. Bodolay
- Biology, MedicineScandinavian journal of immunology
- 1 September 2008
The review aims at describing the complex immune‐regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution ofitamin D in the pathogenesis of human autoimmune diseases.