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Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea‐pig ileum
TLDR
It is felt that the preparation must be used with caution to ascertain the EP1 agonist or antagonist potencies of novel compounds, and that EP2‐receptors may be involved in the PGE action, in view of the marked effect of morphine on the contractile actions of misoprostol,11‐deoxy PGE2‐1‐alcohol, 11‐de oxygen PGE1 and butaprost. Expand
Potent contractile actions of prostanoid EP3‐receptor agonists on human isolated pulmonary artery
TLDR
The study has shown that in the majority of experiments on the human isolated pulmonary artery, the contractile EP3 system outweighed the relaxant EP2 system, and in two experiments the reverse was true. Expand
Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations
The current study examined the utility of the recently described prostacyclin (prostanoid IP) receptor antagonist RO1138452 (2‐(4‐(4‐isopropoxybenzyl)‐phenylamino) imidazoline) as a tool forExpand
Heterogeneity of thromboxane A2 (TP‐) receptors: evidence from antagonist but not agonist potency measurements
TLDR
The excellent agreement for both full and partial agonist potencies between the six preparations provides no evidence for TP‐receptor subtypes and further suggests that the agonist recognition sites of the TP‐ receptors could be very similar, if not identical, in nature. Expand
Focus on prostacyclin and its novel mimetics.
TLDR
New evidence suggests that IP receptor agonists have interesting actions outside of the cardiovascular system, even extending to the release of non-adrenergic non-cholinergic (NANC) transmitters from enteric neurones. Expand
Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues
TLDR
Sulprostone is a suitable agonist for further study of this system and in particular the nature of the G‐protein linkage(s) involved, and it is suggested that it is prudent to describe the human platelet receptor as ‘EP3‐like’. Expand
Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues
TLDR
The data support the hypothesis that there are two subtypes of the PGE receptor; ZK 96480 has minimal activity on both receptor subtypes and appears to be a highly specific PGI2 mimetic. Expand
Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery.
TLDR
The findings implicate an EP(3) receptor in the prostanoid component of contractile synergism, while the synergism predominantly operates through a Ca(2+) influx-Rho-kinase pathway, the EP( 3) receptor does not necessarily transduce via Rho-Kinase. Expand
Comparison of clinical signs, diagnostic findings, organisms isolated, and clinical outcome in dogs with bacterial pneumonia: 93 cases (1986-1991).
TLDR
Clinical outcome was favorable when antimicrobials were selected on the basis of antimicrobial susceptibility results for the other bacterial isolates and not on results of the antimicrobial activity against Mycoplasma spp. Expand
ANTAGONISM OF THE THROMBOXANE‐SENSITIVE CONTRACTILE SYSTEMS OF THE RABBIT AORTA, DOG SAPHENOUS VEIN AND GUINEA‐PIG TRACHEA
TLDR
The results indicate the presence of three types of prostanoid receptors in the guinea‐pig trachea: thromboxane‐ and P GE‐sensitive systems mediating contraction and a PGE‐sensitive system mediating relaxation. Expand
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