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Structural basis for partial agonist action at ionotropic glutamate receptors
An unresolved problem in understanding neurotransmitter receptor function concerns the mechanism(s) by which full and partial agonists elicit different amplitude responses at equal receptorExpand
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Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Botulinum neurotoxins (BoNTs) are produced by Clostridium botulinum and cause the neuroparalytic syndrome of botulism. With a lethal dose of 1 ng kg-1, they pose a biological hazard to humans and aExpand
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Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase
The Sec6/8 complex, also known as the exocyst complex, is an octameric protein complex that has been implicated in tethering of secretory vesicles to specific regions on the plasma membrane. TwoExpand
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Crystal structure and association behaviour of the GluR2 amino‐terminal domain
Fast excitatory neurotransmission is mediated largely by ionotropic glutamate receptors (iGluRs), tetrameric, ligand‐gated ion channel proteins comprised of three subfamilies, AMPA, kainate and NMDAExpand
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Structural basis of agrin-LRP4-MuSK signaling.
Synapses are the fundamental units of neural circuits that enable complex behaviors. The neuromuscular junction (NMJ), a synapse formed between a motoneuron and a muscle fiber, has contributedExpand
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The amino terminal domain of GluR6 subtype glutamate receptor ion channels
The amino-terminal domain (ATD) of glutamate receptor ion channels, which controls their selective assembly into AMPA, kainate and NMDA receptor subtypes, is also the site of action of NMDA receptorExpand
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Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors
Ligand-gated ion channels involved in the modulation of synaptic strength are the AMPA, kainate, and NMDA glutamate receptors. Small molecules that potentiate AMPA receptor currents relieve cognitiveExpand
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Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex
Piercing Botulinum's Defense Botulinum neurotoxins (BoNTs) are poisons that cause muscle paralysis. In the acidic intestine, ingested BoNTs are protected within a progenitor toxin complex. The toxinsExpand
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Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity
Botulinum neurotoxins (BoNTs) are produced by Clostridium botulinum and cause the fatal disease botulism, a flaccid paralysis of the muscle. BoNTs are released together with several auxiliaryExpand
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Botulinum Neurotoxin Heavy Chain Belt as an Intramolecular Chaperone for the Light Chain
Author(s): Brunger, Axel T; Breidenbach, Mark A; Jin, Rongsheng; Fischer, Audrey; Santos, Jose S; Montal, Mauricio
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