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Accurate Detection of Outliers and Subpopulations With Pmetrics, a Nonparametric and Parametric Pharmacometric Modeling and Simulation Package for R
Nonparametric population modeling algorithms have a theoretical superiority over parametric methods to detect pharmacokinetic and pharmacodynamic subgroups and outliers within a study population. Expand
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Creatinine Clearance: Bedside Estimate
Excerpt To the editor: Previously described computer programs have shown their ability to estimate endogenous creatinine clearance (Ccr) with reasonable accuracy when urine specimens cannot be obta...
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Voriconazole pharmacokinetics and pharmacodynamics in children.
BACKGROUND Voriconazole pharmacokinetic and pharmacodynamic data are lacking in children. METHODS Records at the Childrens Hospital Los Angeles were reviewed for children with > or =1 serumExpand
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Letter: Creatinine clearance: bedside estimate.
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A computer program for estimation of creatinine clearance from unstable serum creatinine levels, age, sex, and weight
Abstract Quantitative appraisal of renal function has been difficult when reliable urine collections from patients cannot be obtained for measurement of endogenous creatinine clearance (CCr) byExpand
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Population pharmacokinetic modeling of isoniazid, rifampin, and pyrazinamide.
Isoniazid (INH), rifampin (RIF), and pyrazinamide (PZA) are the most important drugs for the treatment of tuberculosis (TB). The pharmacokinetics of all three drugs in the plasma of 24 healthy malesExpand
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Population Modeling and Monte Carlo Simulation Study of the Pharmacokinetics and Antituberculosis Pharmacodynamics of Rifampin in Lungs
ABSTRACT Little information exists on the pulmonary pharmacology of antituberculosis drugs. We used population pharmacokinetic modeling and Monte Carlo simulation to describe and explore theExpand
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Aminoglycoside Nephrotoxicity: Modeling, Simulation, and Control
ABSTRACT The main constraints on the administration of aminoglycosides are the risks of nephrotoxicity and ototoxicity, which can lead to acute, renal, vestibular, and auditory toxicities. In theExpand
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Pharmacokinetics of Ethambutol under Fasting Conditions, with Food, and with Antacids
ABSTRACT Ethambutol (EMB) is the most frequent “fourth drug” used for the empiric treatment of Mycobacterium tuberculosis and a frequently used drug for infections caused by Mycobacterium aviumExpand
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