The RNA Polymerase “Switch Region” Is a Target for Inhibitors
- J. Mukhopadhyay, K. Das, R. Ebright
- Biology, ChemistryCell
- 17 October 2008
Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties.
- B. Kunze, R. Jansen, F. Sasse, G. Höfle, H. Reichenbach
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 25 December 1998
A novel macrolide, apicularen A, was produced by several species of the genus Chondromyces, and is chemically closely related to the salicylihalamides A and B from the marine sponge Haliclona sp.
Fungal endophytes and bioprospecting
- T. S. Suryanarayanan, N. Thirunavukkarasu, M. Govindarajulu, F. Sasse, R. Jansen, T. S. Murali
- Biology
- 1 February 2009
Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
- E. Campbell, O. Pavlova, S. Darst
- BiologyEMBO Journal
- 23 February 2005
It is suggested that conformational flexibility of Sor, in contrast to the rigid conformation of Rif, allows Sor to adapt to changes in the binding pocket, which has important implications for drug design against rapidly mutating targets.
Opening and Closing of the Bacterial RNA Polymerase Clamp
- A. Chakraborty, Dongye Wang, R. Ebright
- Biology, ChemistryScience
- 3 August 2012
It is proposed that clamp opening allows DNA to be loaded into and unwound in the RNAP active-center cleft, that DNA loading and unwinding trigger clamp closure, and that clamp closure accounts for the high Stability of initiation complexes and the high stability and processivity of elongation complexes.
The corallopyronins, new inhibitors of bacterial RNA synthesis from Myxobacteria.
- H. Irschik, R. Jansen, G. Höfle, K. Gerth, H. Reichenbach
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 1 February 1985
Three new antibiotics have been isolated from the culture broth of the myxobacterium, Corallococcus (Myxococcus) coralloides, and appear to block specifically eubacterial RNA polymerase.
Archazolid and apicularen: Novel specific V-ATPase inhibitors
- M. Huss, F. Sasse, H. Wieczorek
- Biology, ChemistryBMC Biochemistry
- 4 August 2005
The myxobacterial antibiotics archazolid and apicularen are highly efficient and specific novel inhibitors of V-ATPases.
Rhamnolipids from the rhizosphere bacterium Pseudomonas sp. GRP(3) that reduces damping-off disease in Chilli and tomato nurseries.
- Alok K. Sharma, R. Jansen, M. Nimtz, B. N. Johri, V. Wray
- BiologyJournal of Natural Products
- 19 May 2007
A detailed screening of bacterial isolates from the Central Himalayan region for plant growth promotion and antimycelial activity against Pythium and Phytophthora strains afforded seven isolates, of…
Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
- A. Capell, S. Liebscher, C. Haass
- BiologyJournal of Neuroscience
- 2 February 2011
Alkalizing reagents, specifically those already used in humans for other applications, and vacuolar ATPase inhibitors may be therapeutically used to prevent GRN-dependent neurodegeneration.
7-O-Malonyl Macrolactin A, a New Macrolactin Antibiotic from Bacillus subtilis Active against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococci, and a Small-Colony Variant…
- M. Romero-Tabarez, R. Jansen, G. Molinari
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 May 2006
7-O-malonyl macrolactin A is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.
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