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Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats.
TLDR
It is suggested that XO-derived superoxide induces endothelial dysfunction, thus impairing pulmonary arterial relaxation, and contributes to vascular remodeling in hypoxia-exposed neonatal rats, and targeting XO may represent a superior "antioxidant" strategy to ROS scavengers for neonates with pulmonary hypertension.
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Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat.
TLDR
Examining the role of neutrophils in the rat model of BPD by inhibiting neutrophil influx using SB265610, a selective CXC chemokine receptor-2 antagonist suggests that exposure of the neonatal lung to moderate hyperoxia may enhance postnatal lung growth, provided postnatal pulmonary inflammation is suppressed.
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Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat.
TLDR
It is concluded that hypercapnic acidosis has beneficial effects on pulmonary hypertension and vascular remodeling induced by chronic hypoxia, which is speculated derives from antioxidant properties of CO(2) on the lung and consequent modulating effects on the endothelin pathway.
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Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury.
TLDR
TH-induced by adding CO2 to inspired gas provides consistent protection against lung injury in terms of lung permeability, oxygenation, and lung mechanics after mesenteric ischemia-reperfusion, which further support the emerging evidence for ongoing physiologic study of TH at the bedside.
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Growth factors, postnatal lung growth and bronchopulmonary dysplasia.
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Macrophages as a major source of oxygen radicals in the hyperoxic newborn rat lung.
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8-Isoprostane-induced endothelin-1 production by infant rat pulmonary artery smooth muscle cells is mediated by Rho-kinase.
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Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs.
TLDR
It is reported that arginase expression is increased in the lungs of bleomycin-exposed neonatal rats and that treatment with theArginase inhibitor amino-2-borono-6-hexanoic acid prevented the bleomyin-induced development of pulmonary hypertension and deposition of collagen.
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Rho kinase mediates right ventricular systolic dysfunction in rats with chronic neonatal pulmonary hypertension.
TLDR
Data indicate that pressure unloading and regressed arterial and cardiac remodeling did not lead to recovery of systolic function while right ventricular ROCK activity remained increased, and systemic, but not inhaled, ROCK inhibitor normalized up-regulated ROCK and phosphodiesterase 5 activities in the right ventricle.
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A comprehensive echocardiographic protocol for assessing neonatal right ventricular dimensions and function in the transitional period: normative data and z scores.
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