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Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.
TLDR
Diagnostic criteria for ACLF was established and showed that it is distinct from AD, based not only on the presence of organ failure(s) and high mortality rate but also on age, precipitating events, and systemic inflammation.
Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)
TLDR
The Asian Pacific Association for the Study of the Liver (APASL) set up a working party on acute-on-chronic liver failure (ACLF) in 2004, with a mandate to develop consensus guidelines on various aspects of ACLF relevant to disease patterns and clinical practice in the Asia-Pacific region, and statements that were unanimously approved by the experts were accepted.
Working Party proposal for a revised classification system of renal dysfunction in patients with cirrhosis
TLDR
Accepting this new classification will allow studies into the epidemiology, incidence, prevalence, natural history and the development of new treatments for these subtypes of renal dysfunction in cirrhosis.
Acute-on chronic liver failure.
Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment
TLDR
A systematic computerized search was performed using key words related to ‘partial hepatic resection’ and ‘liver failure’ to review most relevant literature about PLF published in the last 20 years.
Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis
TLDR
Assessment of ACLF patients at 3‐7 days of the syndrome provides a tool to define the emergency of LT and a rational basis for intensive care discontinuation owing to futility.
Intensive care of the patient with cirrhosis
TLDR
Care of critically ill patients with impending multiple organ failure requires a team approach with expertise in both hepatology and critical care, aimed at preventing further deterioration in liver function, reversing precipitating factors, and supporting failing organs.
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