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Angiogenesis in cancer and other diseases
Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of a growing number of… Expand
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
- R. Jain
- 7 January 2005
Solid tumors require blood vessels for growth, and many new cancer therapies are directed against the tumor vasculature. The widely held view is that these antiangiogenic therapies should destroy the… Expand
Molecular mechanisms and clinical applications of angiogenesis
Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish diseases such as cancer. Over the past decade, our understanding of the molecular mechanisms of angiogenesis… Expand
Molecular regulation of vessel maturation
- R. Jain
- Biology, Medicine
- Nature Medicine
- 1 June 2003
The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and specialization of the vessel wall for… Expand
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
A general theoretical framework for transvascular exchange and extravascular transport of fluid and macromolecules in tumors is developed. The resulting equations are applied to the most simple case… Expand
Photodynamic therapy for cancer
The therapeutic properties of light have been known for thousands of years, but it was only in the last century that photodynamic therapy (PDT) was developed. At present, PDT is being tested in the… Expand
Delivering nanomedicine to solid tumors
Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using… Expand
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration of AZD2171-an oral tyrosine kinase inhibitor of VEGF receptors-has… Expand
Transport of molecules in the tumor interstitium: a review.
- R. Jain
- Cancer research
- 15 June 1987
The transport of fluid and solute molecules in the interstitium is governed by the biological and physicochemical properties of the interstitial compartment as well as the physicochemical properties… Expand
Understanding the tumor immune microenvironment (TIME) for effective therapy
The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with… Expand