• Publications
  • Influence
Angiogenesis in cancer and other diseases
TLDR
Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed. Expand
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
  • R. Jain
  • Medicine
  • Science
  • 7 January 2005
TLDR
Emerging evidence supporting an alternative hypothesis is reviewed—that certain antiangiogenic agents can also transiently “normalize” the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery. Expand
Molecular mechanisms and clinical applications of angiogenesis
TLDR
Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies. Expand
Molecular regulation of vessel maturation
  • R. Jain
  • Biology, Medicine
  • Nature Medicine
  • 1 June 2003
The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and specialization of the vessel wall forExpand
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
TLDR
This work shows that in addition to the heterogeneous distribution of blood supply, hindered interstitial transport, and rapid extravascular binding of macromolecules, the elevated interstitial pressure plays an important role in determining the penetration of macROMolecules into tumors. Expand
Photodynamic therapy for cancer
TLDR
PDT is being tested in the clinic for use in oncology — to treat cancers of the head and neck, brain, lung, pancreas, intraperitoneal cavity, breast, prostate and skin. Expand
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.
TLDR
This study provides insight into different mechanisms of action of this class of drugs in recurrent glioblastoma patients and suggests that the timing of combination therapy may be critical for optimizing activity against this tumor. Expand
Transport of molecules in the tumor interstitium: a review.
  • R. Jain
  • Medicine
  • Cancer research
  • 15 June 1987
TLDR
High interstitial pressure and low microvascular pressure may retard extravasation of molecules and cells in the tumor interstitium, especially in large tumors. Expand
Delivering nanomedicine to solid tumors
Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for usingExpand
Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
  • R. Jain
  • Medicine
  • Nature Medicine
  • 1 September 2001
TLDR
It is proposed that this form of therapy, judiciously applied, can normalize the tumor vasculature and improve the delivery of therapeutics. Expand
...
1
2
3
4
5
...