Angiogenesis in cancer and other diseases
Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
- R. Jain
- Biology, MedicineScience
- 7 January 2005
Emerging evidence supporting an alternative hypothesis is reviewed—that certain antiangiogenic agents can also transiently “normalize” the abnormal structure and function of tumor vasculature to make it more efficient for oxygen and drug delivery.
Molecular mechanisms and clinical applications of angiogenesis
Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
Molecular regulation of vessel maturation
- R. Jain
- Biology, MedicineNature Network Boston
- 1 June 2003
The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and specialization of the vessel wall for…
Understanding the tumor immune microenvironment (TIME) for effective therapy
By parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.
A framework for advancing our understanding of cancer-associated fibroblasts
This Consensus Statement issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance the understanding of this important cell type in the tumour microenvironment.
Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection.
Photodynamic therapy for cancer
PDT is being tested in the clinic for use in oncology — to treat cancers of the head and neck, brain, lung, pancreas, intraperitoneal cavity, breast, prostate and skin.
Delivering nanomedicine to solid tumors
Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using…