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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequenceExpand
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Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture. To gainExpand
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A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells
The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster within regions enriched for genes encoding developmentally important transcription factors (TFs). This suggests thatExpand
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Histone H3K27ac separates active from poised enhancers and predicts developmental state
Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. TheseExpand
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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
Cells of a multicellular organism are genetically homogeneous but structurally and functionally heterogeneous owing to the differential expression of genes. Many of these differences in geneExpand
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Polycomb complexes repress developmental regulators in murine embryonic stem cells
The mechanisms by which embryonic stem (ES) cells self-renew while maintaining the ability to differentiate into virtually all adult cell types are not well understood. Polycomb group (PcG) proteinsExpand
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
DNA methylation is essential for normal development and has been implicated in many pathologies including cancer. Our knowledge about the genome-wide distribution of DNA methylation, how it changesExpand
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Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
Mecp2 is an X-linked gene encoding a nuclear protein that binds specifically to methylated DNA (ref. 1) and functions as a general transcriptional repressor by associating with chromatin-remodelingExpand
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Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2)Expand
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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
There is growing recognition that mammalian cells produce many thousands of large intergenic transcripts. However, the functional significance of these transcripts has been particularlyExpand
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