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A computational framework to explore large-scale biosynthetic diversity
TLDR
Two bioinformatic tools enable sequence similarity network and phylogenetic analysis of gene clusters and their families across hundreds of strains and in large datasets, leading to the discovery of new natural products. Expand
A computational framework for systematic exploration of biosynthetic diversity from large-scale genomic data
TLDR
The discovery potential of the BiG-SCAPE platform is demonstrated by using CORASON to comprehensively map the phylogenetic diversity of the large detoxin/rimosamide gene cluster clan, prioritizing three new detoxin families for subsequent characterization of six new analogs using isotopic labeling and analysis of tandem mass spectrometric data. Expand
In Vitro Reconstruction of Nonribosomal Peptide Biosynthesis Directly from DNA Using Cell-Free Protein Synthesis.
TLDR
This work demonstrates the use of cell-free protein synthesis to biosynthesize a cyclic dipeptide with correct absolute stereochemistry and represents a first step to apply cell-based recombinant expression to discover and characterize new natural products. Expand
Enantioselective Synthesis of Allenes by Catalytic Traceless Petasis Reactions.
TLDR
An asymmetric boronate addition to sulfonyl hydrazones catalyzed by chiral biphenols to access enantioenriched allenes in a traceless Petasis reaction is reported, yielding a propargylic diazene that performs an alkyne walk to afford the allene. Expand
Oxidative Coupling of Enolates, Enol Silanes and Enamines: Methods and Natural Product Synthesis.
TLDR
There have been a number of reports from several research groups demonstrating advances in several neglected areas of oxidative coupling, and this microreview summarizes these new advances and provides an overview of recent natural product syntheses that showcase the power of these transformations. Expand
Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer
TLDR
The discovery of tambromycin via large-scale correlation of gene clusters with metabolites illuminates a path for structure-based discovery of natural products at a sharply increased rate. Expand
Highly Oxygenated Multifunctional Compounds in α-Pinene Secondary Organic Aerosol.
TLDR
This study shows that highly oxygenated molecules that contain multiple peroxide functionalities are readily cationized by the attachment of Na+ during electrospray ionization operated in the positive ion mode, providing new and direct molecular-level information for a key component needed for achieving carbon mass closure of α-pinene SOA. Expand
Elucidating the Rimosamide-Detoxin Natural Product Families and Their Biosynthesis Using Metabolite/Gene Cluster Correlations.
TLDR
The rimosamides were found to antagonize the antibiotic activity of blasticidin S against Bacillus cereus and are definitively assigned to nonlinear biosynthetic pathways via heterologous expression in Streptomyces lividans. Expand
Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics.
TLDR
The discovery of the tyrobetaines shows the great potential of metabologenomics combined with molecular networking and computational structure prediction for identifying interesting biosynthetic reactions and novel NPs. Expand
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