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Half-time analysis of the integrated Michaelis equation. Simulation and use of the half-time plot and its direct linear variant in the analysis of some alpha-chymotrypsin, papain- and…

- C. Wharton, R. J. Szawelski
- Mathematics, Medicine
- The Biochemical journal
- 1 May 1982

Substitution of half-time parameters in the integrated form of the Michaelis-Menten equation for any enzyme-catalysed reaction yields an equation that gives a linear relationship between the… Expand

Kinetic solvent isotope effects on the deacylation of specific acyl-papains. Proton inventory studies on the papain-catalysed hydrolyses of specific ester substrates: analysis of possible transition…

- R. J. Szawelski, C. Wharton
- Chemistry, Medicine
- The Biochemical journal
- 1 December 1981

1. The hydrolyses of the p-nitrophenyl esters of N-benzyloxycarbonylglycine, alpha-N-benzyloxycarbonyl-L-lysine and N-methoxycarbonyl-L-phenylalanylglycine catalysed by papain (EC 3.4.22.2) have been… Expand

Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic…

- K. Brocklehurst, D. Kowlessur, +6 authors R. J. Szawelski
- Chemistry, Medicine
- The Biochemical journal
- 15 March 1988

1. The pH-dependences of the second-order rate constant (k) for the reactions of papain (EC 3.4.22.2) with 2-(acetamido)ethyl 2'-pyridyl disulphide and with ethyl 2-pyridyl disulphide and of k for… Expand

Benzyloxycarbonylphenylalanylcitrulline p-nitroanilide as a substrate for papain and other plant cysteine proteinases.

- C. J. Gray, J. Boukouvalas, R. J. Szawelski, C. Wharton
- Biology, Medicine
- The Biochemical journal
- 1 April 1984

After preliminary assays, with papain, bromelain and ficin, on a range of citrulline p-nitroanilides, values of Km and kcat. for the papain-catalysed hydrolysis of three derivatives, N alpha-… Expand

Nuclear-magnetic-resonance and Fourier-transform infrared spectroscopic studies of the hydrogen—deuterium exchange of thiol groups: determination of the fractionation factor

- R. J. Szawelski, C. Wharton, S. White
- Chemistry
- 1 August 1982

Real-time analysis of progress curves of enzyme-catalysed reactions

- C. Wharton, R. J. Szawelski
- Chemistry
- 1 August 1982

Ultraviolet resonance Raman spectroscopy of a highly specific acyl-papain

- P. Tonge, C. Wharton, R. J. Szawelski, P. Killough, R. Hester
- Chemistry
- 1 October 1985