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Genetic Diversity in the Modern Horse Illustrated from Genome-Wide SNP Data
Horses were domesticated from the Eurasian steppes 5,000–6,000 years ago. Since then, the use of horses for transportation, warfare, and agriculture, as well as selection for desired traits andExpand
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Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds
Intense selective pressures applied over short evolutionary time have resulted in homogeneity within, but substantial variation among, horse breeds. Utilizing this population structure, 744Expand
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Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy
Gene editing and muscular dystrophy Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness and a shortened life span. The disease is caused by mutations that reduce orExpand
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A Duchenne Muscular Dystrophy Gene Hot Spot Mutation in Dystrophin-Deficient Cavalier King Charles Spaniels Is Amenable to Exon 51 Skipping
Background Duchenne muscular dystrophy (DMD), which afflicts 1 in 3500 boys, is one of the most common genetic disorders of children. This fatal degenerative condition is caused by an absence orExpand
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European outbreaks of atypical myopathy in grazing equids (2006-2009): spatiotemporal distribution, history and clinical features.
REASONS FOR PERFORMING STUDY Improved understanding of the epidemiology of atypical myopathy (AM) will help to define the environmental factors that permit or support the causal agent(s) to exertExpand
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Epidemiology of Exertional Rhabdomyolysis Susceptibility in Standardbred Horses Reveals Associated Risk Factors and Underlying Enhanced Performance
Background Exertional rhabdomyolysis syndrome is recognised in many athletic horse breeds and in recent years specific forms of the syndrome have been identified. However, although StandardbredExpand
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Variability of resting endoscopic grading for assessment of recurrent laryngeal neuropathy in horses.
REASONS FOR PERFORMING STUDY The extent to which variability affects endoscopic grading of arytenoid cartilage movement is uncertain. OBJECTIVE To determine the observer and within horseExpand
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Vitamin E and exertional rhabdomyolysis during endurance sled dog racing
Exertional rhabdomyolysis (ER) is common in sled dogs, animals with high energy expenditures that consume high fat (60% of ingested calories) diets. Associations between pre-race plasma [vitamin E]Expand
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Retrospective analysis of post-mortem findings in 1,444 aged donkeys.
The aim of this study was to describe and report the prevalence of conditions found at necropsy examination of UK donkeys. Records from 1,444 donkeys over a 7-year period were included in theExpand
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European outbreaks of atypical myopathy in grazing horses (2006-2009): determination of indicators for risk and prognostic factors.
REASONS FOR PERFORMING STUDY Appropriate management of atypical myopathy (AM) requires the establishment of an accurate diagnosis and prognosis. Furthermore, preventive measures to avoid AM need toExpand
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