• Publications
  • Influence
One-Step Surgical Procedure for the Treatment of Osteochondral Defects with Adipose-Derived Stem Cells in a Caprine Knee Defect: A Pilot Study
Abstract Regenerative therapies offer attractive alternatives for the treatment of osteochondral defects. Adipose-derived stromal vascular fraction (SVF) cells allow the development of one-stepExpand
  • 63
  • 3
  • PDF
Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future
•  Introduction •  Degenerative disc disease and emerging biological treatment approaches •  Stem cell sources •  Integration of ASC‐based regenerative medicine and surgery •  In vitro studies ‐ Expand
  • 86
  • 2
  • PDF
Rapid attachment of adipose stromal cells on resorbable polymeric scaffolds facilitates the one‐step surgical procedure for cartilage and bone tissue engineering purposes
The stromal vascular fraction (SVF) of adipose tissue provides an abundant source of mesenchymal stem cells. For clinical application, it would be beneficial to establish treatments in which SVF isExpand
  • 54
  • 1
Caprine articular, meniscus and intervertebral disc cartilage: an integral analysis of collagen network and chondrocytes.
Cartilage is a tissue with only limited reparative capacities. A small part of its volume is composed of cells, the remaining part being the hydrated extracellular matrix (ECM) with collagens andExpand
  • 44
  • 1
Osteogenic differentiation strategies for adipose-derived mesenchymal stem cells.
Adipose stem cell preparations, either obtained as a freshly isolated so-called stromal vascular fraction (SVF) or as cells cultured to homogeneity and then referred to as adipose stem cells (ASCs),Expand
  • 32
  • 1
Reproducible Long-term Disc Degeneration in a Large Animal Model
Study Design. Twelve goats were chemically degenerated and the development of the degenerative signs was followed for 26 weeks to evaluate the progression of the induced degeneration. The resultsExpand
  • 77
Biodegradable Polymers in Bone Tissue Engineering
The use of degradable polymers in medicine largely started around the mid 20th century with their initial use as in vivo resorbing sutures. Thorough knowledge on this topic as been gained since thenExpand
  • 77
  • PDF
The effect of ethylene oxide, glow discharge and electron beam on the surface characteristics of poly(L-lactide-co-caprolactone) and the corresponding cellular response of adipose stem cells.
Bioabsorbable polymers are increasingly being used in tissue engineering strategies. Despite the knowledge that some sterilization techniques may affect the physical properties of these polymers,Expand
  • 18
Relation between radiological assessment and biomechanical stability of lumbar interbody fusion in a large animal model
PurposeTo relate the progress of vertebral segmental stability after interbody fusion surgery with radiological assessment of spinal fusion.MethodsTwenty goats received double-level interbody fusionExpand
  • 10
Reaming debris as a novel source of autologous bone to enhance healing of bone defects.
Reaming debris is formed when bone defects are stabilized with an intramedullary nail, and contains viable osteoblast-like cells and growth factors, and might thus act as a natural osteoinductiveExpand
  • 7