Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo.
- Ken-ichi Ogawara, M. Rots, +5 authors G. Molema
- Biology, Medicine
- Human gene therapy
- 7 July 2004
To assess the possibilities of retargeting adenovirus to activated endothelial cells, we conjugated bifunctional polyethylene glycol (PEG) onto the adenoviral capsid to inhibit the interaction… Expand
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature.
- K. Temming, R. Schiffelers, G. Molema, R. J. Kok
- Biology, Medicine
- Drug resistance updates : reviews and…
- 1 December 2005
During the past decade, RGD-peptides have become a popular tool for the targeting of drugs and imaging agents to alphavbeta3-integrin expressing tumour vasculature. RGD-peptides have been introduced… Expand
Anti-tumor efficacy of tumor vasculature-targeted liposomal doxorubicin.
- R. Schiffelers, G. Koning, +6 authors G. Storm
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 28 August 2003
Angiogenesis is a key process in the growth and metastasis of a tumor. Disrupting this process is considered a promising treatment strategy. Therefore, a drug delivery system specifically aiming at… Expand
Targeting tumors with nanobodies for cancer imaging and therapy.
- S. Oliveira, Raimond Heukers, J. Sornkom, R. J. Kok, P. M. P. van Bergen en Henegouwen
- Biology, Medicine
- Journal of controlled release : official journal…
- 28 December 2013
The use of monoclonal antibodies has revolutionized both cancer therapy and cancer imaging. Antibodies have been used to directly inhibit tumor cell proliferation or to target drugs to tumors. Also… Expand
How to screen non-viral gene delivery systems in vitro?
- E. V. van Gaal, R. van Eijk, +4 authors E. Mastrobattista
- Biology, Medicine
- Journal of controlled release : official journal…
- 25 September 2011
Screening of new gene delivery candidates regarding transfection efficiency and toxicity is usually performed by reading out transgene expression levels relative to a reference formulation after in… Expand
The VEGF/Rho GTPase signalling pathway: a promising target for anti-angiogenic/anti-invasion therapy.
- R. van der Meel, M. Symons, +5 authors A. Byrne
- Biology, Medicine
- Drug discovery today
- 1 March 2011
It has become increasingly apparent that current antiangiogenic therapy elicits modest effects in clinical settings. In addition, it remains challenging to treat cancer metastasis through… Expand
Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro.
- J. Kułdo, J. Westra, +6 authors G. Molema
- Biology, Medicine
- American journal of physiology. Cell physiology
- 1 November 2005
Endothelial cells actively participate in inflammatory events by regulating leukocyte recruitment via the expression of inflammatory genes such as E-selectin, VCAM-1, ICAM-1, IL-6, IL-8, and… Expand
Diverse origins of the myofibroblast—implications for kidney fibrosis
- L. Falke, S. Gholizadeh, R. Goldschmeding, R. J. Kok, T. Nguyen
- Medicine
- Nature Reviews Nephrology
- 1 April 2015
Fibrosis is the common end point of chronic kidney disease. The persistent production of inflammatory cytokines and growth factors leads to an ongoing process of extracellular matrix production that… Expand
Drug targeting to the kidney: Advances in the active targeting of therapeutics to proximal tubular cells.
- M. Dolman, S. Harmsen, G. Storm, W. Hennink, R. J. Kok
- Medicine
- Advanced drug delivery reviews
- 30 November 2010
Activated signaling cascades in the proximal tubular cells of the kidneys play a crucial role in the development of tubulointerstitial fibrosis. Inhibition of these signaling cascades with locally… Expand
Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis.
- G. Koning, R. Schiffelers, +5 authors G. Storm
- Medicine
- Arthritis and rheumatism
- 1 April 2006
OBJECTIVE
To investigate whether RGD peptide-exposing long circulating polyethylene glycol (PEG) liposomes (RGD-PEG-L) targeted to alphavbeta3 integrins expressed on angiogenic vascular endothelial… Expand