• Publications
  • Influence
Cleavage‐site preferences of Sindbis virus polyproteins containing the non‐structural proteinase. Evidence for temporal regulation of polyprotein processing in vivo.
The non‐structural proteins of Sindbis virus, nsP1, 2, 3 and 4, are produced upon cleavage of polyproteins P123 and P1234 by a proteinase residing in nsP2. We used cell free translation of SP6Expand
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Natural History of a Recurrent Feline Coronavirus Infection and the Role of Cellular Immunity in Survival and Disease
The genus Coronavirus (family Coronaviridae, order Nidovirales) comprises a group of enveloped positive-strand RNA viruses of mammals and birds. With a genome of 27 to 31 kb, encoding an ∼750-kDaExpand
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Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study Group
The present outbreak of lower respiratory tract infections, including respiratory distress syndrome, is the third spillover, in only two decades, of an animal coronavirus to humans resulting in aExpand
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Structure, function and evolution of the hemagglutinin-esterase proteins of corona- and toroviruses
  • R. J. Groot
  • Biology
  • Glycoconjugate Journal
  • 1 February 2006
Virus attachment to host cells is mediated by dedicated virion proteins, which specifically recognize one or, at most, a limited number of cell surface molecules. Receptor binding often involvesExpand
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Feline infectious peritonitis : insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3 c gene
Received 9 September 2009 Accepted 29 October 2009 Feline infectious peritonitis (FIP) is a lethal systemic disease caused by FIP virus (FIPV), a virulent mutant of apathogenic feline entericExpand
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Homologous RNA recombination allows efficient introduction of site- specific mutations into the genome of coronavirus MHV-A59 via synthetic co-replicating RNAs
We describe a novel strategy to site-specifically mutagenize the genome of an RNA virus by exploiting homologous RNA recombination between synthetic defective interfering (DI) RNA and the viral RNA. Expand
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Sequence analysis of the 3'-end of the feline coronavirus FIPV 79-1146 genome: comparison with the genome of porcine coronavirus TGEV reveals large insertions.
The genetic information, carried on mRNA 6 of feline infectious peritonitis virus (FIPV) strain 79-1146, was determined by sequence analysis of cDNA clones derived from the 3' end of the FIPV genome.Expand
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Molecular cloning and expression of rat interferon-γ
Interferon-y (IFN-y) has been extensively studied in the mouse system. Produced by activated T cells and natural killer (NK) cells, this lymphokine possesses antiviral activity and exerts pleiotropicExpand
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