• Publications
  • Influence
The conformational analysis of bafilomycin A1
The 1H and 13C n.m.r. spectra of bafilomycin A1, (1a), have been unambiguously solved by two-dimensional (2D) n.m.r. methods. Comparison of this spectral data with that reported for two otherExpand
A conformational study of bafilomycin A1 by x-ray crystallography and nmr techniques
Abstract We report the structure determination of bafilomycin A1 by X-ray crystallography and a reassignment of the 1H and 13C NMR spectra. By the measurement of 13C NT1 and n.O.e. values theExpand
A novel series of milbemycin antibiotics from Streptomyces strain E225. II. Isolation, characterization, structure elucidation and solution conformations.
A novel series of milbemycin antibiotics were isolated from the fermentation broth of a Streptomyces species designated E225 and the structures of the four main metabolites were determined by NMR techniques. Expand
Synthesis and anthelmintic activity of a series of pyrazino[2,1-a][2]benzazepine derivatives.
A series of 1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-alpha][2] benzazepine derivatives was prepared and the cestocidal activity of the compounds evaluated in an in vitro Taenia crassiceps screen. ManyExpand
Further novel milbemycin antibiotics from Streptomyces sp. E225. Fermentation, isolation and structure elucidation.
Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of theExpand
Isothiourea derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole with broad-spectrum anthelmintic activity.
These derivatives of 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole have an improved spectrum of activity over tetramisole and are active against nematodes, cestodes, and trematodes. Expand
Novel long-range isotope effects in a macrolide antibiotic: bafilomycin A1
The 1H and 13C NMR spectra of bafilomycin A1(1), 21-O-trimethylsilylbafilomycin A1(2) and 7-O-acetyl-21-O-t-butyldimethylsilylbafilomycin A1(3) have been unambiguously solved in a variety of solventsExpand
Formation of certain substituted 5H-pyrrolo[2,3-b]pyrazines by thermal cyclisation of pyrazinylhydrazones and a route to 5H-pyrazino[2,3-b]indole; a synthesis of 5H-pyrrolo[2,3-b] pyrazine and some
Thermal (non-catalytic) cyclisation of the pyrazinylhydrazones (6a—i) caused ring closure on to the carbon atom of the pyrazine nucleus to give the 3-substituted and 2,3-disubstitutedExpand
An investigation of the stereochemistry of a 22,23-dioxygenated milbemycin
Abstract We report NMR studies on a known 22,23-dioxygenated milbemycin which show that the 22 and 23 oxygen atoms are trans diequatorial (I) and not trans diaxial (II) as previously reported1. TheExpand
A Practical Synthesis of the Milbemycin SB‐201561.
Abstract A 6-step synthesis of the potent anthelmintic SB-201561 is described. The key stage of the synthesis is a novel Beckmann type oxime fragmentation to give a lactone, followed by a 2-stepExpand