• Publications
  • Influence
Ultra-short acting beta-blockers: a proposal for the treatment of the critically ill patient.
Beta-blockade is of proven value in the therapy of acute myocardial infarction but, unfortunately, may produce cardiac failure by removal of needed sympathetic support. The long duration of action ofExpand
  • 67
Prolonged apomorphine-like behavioural effects of apomorphine esters
Abstract In vitro and in vivo activities of a series of O , O ′-diesters of apomorphine, including diacetyl-, dipropionyl-, diisobutyryl-, dipivaloyl-, and dibenzoylapomorphine, were evaluated in theExpand
  • 39
Hydrolysis of diester prodrugs of apomorphine.
Abstract O,O′-diesters of apomorphine exert behavioral effects identical to those of apomorphine, but prolonged in proportion to the bulk of the esters. This prolonged activity may reflect depotExpand
  • 24
Alpha-methyldopamine derivatives. Synthesis and pharmacology.
  • 18
Esters of apomorphine and N,N-dimethyldopamine as agonists of dopamine receptors in the rat brain in vivo
Abstract Subcutaneous injections of O,O'-diacetylapomorphine, at doses of 0.1 to 10.0 mg kg , produced stereotyped gnawing behaviour in the rat, indistinguishable from that induced by apomorphine.Expand
  • 21
Diester derivatives as apomorphine prodrugs.
A series of diesters of apomorphine was synthesized to serve as prodrugs. They were converted in vivo to free apomorphine, which could be detected in the brain. Stereotyped gnawing behavior andExpand
  • 26
[(Arylcarbonyl)oxy]propanolamines. 1. Novel beta-blockers with ultrashort duration of action.
Novel [(arylcarbonyl)oxy]propanolamines were synthesized and investigated as potential ultrashort-acting beta-adrenergic receptor blockers. Many of these analogues exhibited good potency and shortExpand
  • 22
...
1
2
3
...