Synthetic Routes to Quinoline Derivatives: Novel Syntheses of 3-Butyryl-8-methoxy-4-[(2-methylphenyl)amino]quinoline and 3-Butyryl-8-(2-hydroxyethoxy)-4-[(2-methylphenyl)amino]quinoline
- R. J. Atkins, Gary Francis GlaxoSmithKline Breen, C. Wicks
- Chemistry
- 15 May 1997
The 3,4,8-trisubstituted quinoline derivatives 2-butyryl-8-methoxy-4-[(2-methylphenyl)amino]quinoline and 3-butyryl-8-(2-hydroxyethoxy)-4-[(2-methylphenyl)amino]quinoline were prepared using five…
The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 2: Conversion of the Key Intermediate SB-235349 to SB-214857-A
- R. J. Atkins, Adam Banks, A. Wells
- Chemistry
- 26 July 2003
The process development to the manufacturing route to (2S)-7-([4,4‘-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid hydrochloride (SB-214857-A,…
The Development of a Manufacturing Route for the GPIIb/IIIa Receptor Antagonist SB-214857-A. Part 1: Synthesis of the Key Intermediate 2,3,4,5-Tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic…
- Ian P. Andrews, R. J. Atkins, A. Wells
- Chemistry
- 26 July 2003
The development of an efficient manufacturing route to 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester SB-235349, a key intermediate in the synthesis of lotrafiban…
A new synthesis of the GPIIb/IIIa receptor antagonist SB-214857-A
- Ian P. Andrews, R. J. Atkins, A. Wells
- Chemistry
- 16 July 2001
Synthesis of (5R)-(Z)-6-(1-methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid, a potent broad spectrum β-lactamase inhibitor, from 6-aminopenicillanic acid
- N. F. Osborne, R. J. Atkins, G. Walker
- Chemistry
- 1994
(5R)-(Z)-6-(1-Methyl-1,2,3-triazol-4-ylmethylene)penem-3-carboxylic acid 34(BRL 42715) has been prepared from 6-aminopenicillanic acid 4(6-APA) by a short, stereoselective and efficient route via the…
Reaction of cyclo-octatetraene and its derivatives, Part VI. Stereochemistry of the benzene-acrylonitrile[2+2]photo-adduct.☆
- R. J. Atkins, G. Fray, A. Gilbert
- Chemistry
- 1975
The stereochemistry of 1,2-photocycloaddition of vinylic compounds to benzene
- R. J. Atkins, G. Fray, A. Gilbert, M. W. Samsudin, Andrew J. K. Steward, G. Taylor
- Chemistry
- 11 March 1980
The stereochemistry of the 1,2-photocycloaddition of benzene to acrylonitrile, methyl acrylate, methyl methacrylate, methyl vinyl ketone, ethyl vinyl ether, butyl vinyl ether, 2,3-dihydropyran, and…
Synthesis of (5R)-(Z)-6-(1-Methyl-1,2,3-triazol-4-ylmethylene)penem-3- carboxylic Acid, a Potent Broad Spectrum β-Lactamase Inhibitor, from 6-Aminopenicillanic Acid.
- N. F. Osborne, R. J. Atkins, G. Walker
- Chemistry
- 3 May 1994
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