• Publications
  • Influence
IMP-GMP 5'-nucleotidase.
  • R. Itoh
  • Chemistry, Medicine
  • Comparative biochemistry and physiology. B…
  • 1 May 1993
Regulation of rat heart cytosol 5'-nucleotidase by adenylate energy charge.
TLDR
The possibility that this enzyme participates in production of adenosine, a vasodilator, during Hypoxia and in removal of IMP, which accumulates during the hypoxia, in the heart is suggested. Expand
Purification and some properties of cytosol 5'-nucleotidase from rat liver.
  • R. Itoh
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 13 February 1981
TLDR
Results provided consistent evidence for the identity of this enzyme and the cytosol 5'-nucleotidase, the presence of which had been reported in crude preparations from rat liver. Expand
5'-nucleotidase of chicken liver.
TLDR
This is the first time it has been possible to obtain 5′-nucleotidase from the hepatic tissue of uricotelic animals and it was found to be kinetically distinct from 5-ribonucleotide phosphophydrolase obtained from other sources. Expand
Studies on some molecular properties of cytosol 5'-nucleotidase from rat liver.
  • R. Itoh
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 5 May 1982
TLDR
It is suggested that adenine nucleotides, which are activators of the enzyme, induce its conformational change and the enzyme most likely exists in the native state as a tetramer. Expand
Enzymatic properties and physiological roles of cytosolic 5'-nucleotidase II.
  • R. Itoh
  • Chemistry, Medicine
  • Current medicinal chemistry
  • 31 October 2013
TLDR
Results suggest that cN-II participates, through IMP dephosphorylation, in production of uric acid as the main end product of aminonitrogen in these animals. Expand
Changes in 5'-nucleotidase activity in chick liver during development and dietary treatment.
TLDR
The results suggest that the 5′-nucleotidase, which has been described by us previously 1 , would play a role in the excretory metabolism of α-amino nitrogen of amino acid in a uricotelic animal. Expand
Mechanism of porphobilinogen synthase. Possible role of essential thiol groups.
TLDR
Peptide fingerprints, molecular sieve, and cation exchange chromatography of tryptic digests of the enzyme inactivated by iodo[Wlacetate or by iodacetamide demonstrated that each reagent alkylated a cysteinyl residue which gave rise to a different radioactive tryptic peptide. Expand
Regulation of cytosol 5'-nucleotidase by adenylate energy charge.
  • R. Itoh
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 14 May 1981
In the physiological range of the adenylate energy charge in liver (0.7-0.9), th rate of AMP-hydrolysis catalysed by rat liver cytosol 5'-nucleotidase (5'-ribonucleotide phosphohydrolase, EC 3.1.3.5)Expand
Kinetic properties of cytosol 5'-nucleotidase from chicken liver.
TLDR
A highly purified preparation of cytosol 5′-nucleotidase (5′-ribonucleotide phosphohydrolase, EC 3.3.5) from chicken liver was effectively activated by ATP and inhibited by P i, and it seems likely that this enzyme is an allosteric protein regulated by various ligands through conformational changes. Expand
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