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Lysenin: A new tool for investigating membrane lipid organization
Sphingomyelin is a major sphingolipid species in animal cells and is a major lipid constituent of plasma membranes. Recent reports have established important roles for sphingomyelin and itsExpand
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Glycosaminoglycan Binding Properties of Annexin IV, V, and VI*
We have previously demonstrated that annexin IV, one of the calcium/phospholipid-binding annexin family proteins, binds to glycosaminoglycans (GAGs) in a calcium-dependent manner (Kojima, K.,Expand
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Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution[S]
An automated fluorescence microscopy assay using a nontoxic cholesterol binding protein, θ toxin domain 4, (D4), was developed in order to identify chemical compounds modifying intracellularExpand
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A lipid-specific toxin reveals heterogeneity of sphingomyelin-containing membranes.
Little is known about the heterogenous organization of lipids in biological membranes. Sphingomyelin (SM) is a major plasma membrane lipid that forms lipid domains together with cholesterol andExpand
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Imaging lipid rafts.
Lipid rafts are plasma membrane microdomains enriched in sphingolipids and cholesterol. These domains have been suggested to serve as platforms for various cellular events, such as signaling andExpand
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Binding of a pleurotolysin ortholog from Pleurotus eryngii to sphingomyelin and cholesterol-rich membrane domains[S]
A mixture of sphingomyelin (SM) and cholesterol (Chol) exhibits a characteristic lipid raft domain of the cell membranes that provides a platform to which various signal molecules as well as virusExpand
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[Imaging lipid rafts].
: Lipid rafts are plasma membrane microdomains enriched in sphingolipids and cholesterol. These domains have been suggested to serve as platforms for various cellular events, such as signaling andExpand
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Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT Protein-dependent Extraction of Ceramides from the Endoplasmic Reticulum*
Background: Pharmacological inhibitors of sphingolipid metabolism and transport are useful for both biological and therapeutic research. Results: High throughput microscopy-based screening identifiedExpand
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Detectors for evaluating the cellular landscape of sphingomyelin- and cholesterol-rich membrane domains.
Although sphingomyelin and cholesterol are major lipids of mammalian cells, the detailed distribution of these lipids in cellular membranes remains still obscure. However, the recent development ofExpand
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Targeting cholesterol in a liquid-disordered environment by theonellamides modulates cell membrane order and cell shape.
Roles of lipids in the cell membrane are poorly understood. This is partially due to the lack of methodologies, for example, tool chemicals that bind to specific membrane lipids and modulate membraneExpand
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