Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity.
- Wei Ying, Y. S. Lee, Wenxian Fu
- Biology, MedicineCell Metabolism
- 5 February 2019
Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases
- Y. Levkovitz, Galit Ben-shushan, Y. Zick
- Biology, MedicineMolecular and Cellular Neuroscience
- 1 November 2007
Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.
- R. Isaac, S. Boura-Halfon, Diana Gurevitch, A. Shainskaya, Y. Levkovitz, Y. Zick
- MedicineJournal of Biological Chemistry
- 23 March 2018
Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic cells and does not affect the results or conclusions of this work.
Exosomes as mediators of intercellular crosstalk in metabolism.
- R. Isaac, F. C. Reis, Wei Ying, J. Olefsky
- BiologyCell Metabolism
- 7 September 2021
Selective Serotonin Reuptake Inhibitors (SSRIs) Inhibit Insulin Secretion and Action in Pancreatic β Cells*
- R. Isaac, S. Boura-Halfon, Diana Gurevitch, A. Shainskaya, Y. Levkovitz, Y. Zick
- Biology, MedicineJournal of Biological Chemistry
- 28 December 2012
It is suggested that SSRIs inhibit insulin secretion; induce the unfolded protein response; activate an apoptotic process, and trigger β cell death, which might accelerate the transition from an insulin-resistant state to overt diabetes.
TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance.
- Dalila El Ouarrat, R. Isaac, J. Olefsky
- Biology, ChemistryCell Metabolism
- 23 October 2019
Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets
Use of dispersed human islets provides a new platform for functional HTS in a highly physiological system and identifies new targets, such as OTUB2, for therapeutic intervention in type 1 diabetes and islet transplantation.
TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response
- R. Isaac, I. Goldstein, Y. Zick
- BiologyCell Death and Differentiation
- 14 October 2016
It is shown that seven-transmembrane superfamily member 3 maintains protein homeostasis and promotes cell survival through attenuation of ER stress and silencing of p53 promotes p53 activity, suggesting the existence of a negative-feedback loop.
The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice
- H. Shatz-Azoulay, Y. Vinik, R. Isaac, Ulrike Kohler, S. Lev, Y. Zick
- BiologyScientific Reports
- 30 April 2020
The existence of a ‘vicious cycle’ whereby gal-8 secreted by the tumor microenvironment, promotes secretion of chemoattractants at the metastatic niche that promote further recruitment of tumor cells to that site is suggested.
Prolonged insulin treatment sensitizes apoptosis pathways in pancreatic β cells.
It is concluded that prolonged elevated levels of insulin may prime apoptosis and cell death-inducing mechanisms as a result of oxidative stress in pancreatic cells.
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