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Myelodysplastic Syndrome and Benzene Exposure Among Petroleum Workers: An International Pooled Analysis
Background Benzene at high concentrations is known to cause acute myeloid leukemia (AML), but its relationship with other lymphohematopoietic (LH) cancers remains uncertain, particularly at lowExpand
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An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure.
Benzene-induced myelotoxicity can be reproduced by the coadministration of two principal metabolites, phenol and hydroquinone. Coadministration of phenol (75 mg/kg) and hydroquinone (25-75 mg/kg)Expand
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Peripheral blood effects in benzene-exposed workers.
The hematotoxic effects of benzene exposure may be important in the occurrence of subsequent health effects. We sought to provide further information on peripheral blood effects by studying 928Expand
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An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.
The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protectingExpand
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Analysis of hydroquinone and catechol in peripheral blood of benzene-exposed workers.
We have developed a gas chromatography-mass spectrometry method for analysis of benzene (BZ) metabolites in human urine and blood. Here we describe peripheral blood concentrations of hydroquinoneExpand
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Benzene disposition in the rat after exposure by inhalation.
Abstract Little information is available on benzene disposition after exposure by inhalation despite the importance of this route in man. Benzene metabolites as a group have been measured in boneExpand
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Quinones as toxic metabolites of benzene.
  • R. Irons
  • Biology, Medicine
  • Journal of toxicology and environmental health
  • 1985
Occupational exposure to benzene has long been associated with toxicity to the blood and bone marrow, including lymphocytopenia, pancytopenia, aplastic anemia, acute myelogenous leukemia, andExpand
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Aggressive Natural Killer Cell Leukemia: Report of a Chinese Series and Review of the Literature
Aggressive natural killer cell leukemia (ANKL) is a rare Epstein-Barr virus (EBV)-associated fulminating disease that is widely disseminated at diagnosis. Because of its typically extranodalExpand
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A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China
The frequency of subtypes of lymphoid neoplasms was determined in a prospective series of 831 patients presenting at 29 Shanghai hospitals over a 4-year period. Diagnosis and classification wasExpand
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Chronic exposure to benzene results in a unique form of dysplasia.
Hematotoxicity following chronic benzene exposure has been recognized for over a century, although the mechanism remains unknown. We describe a novel form of bone marrow dysplasia in 23 workersExpand
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