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- Publications
- Influence
Myelodysplastic Syndrome and Benzene Exposure Among Petroleum Workers: An International Pooled Analysis
- A. Schnatter, D. Glass, G. Tang, R. Irons, L. Rushton
- Medicine
- Journal of the National Cancer Institute
- 20 November 2012
Background Benzene at high concentrations is known to cause acute myeloid leukemia (AML), but its relationship with other lymphohematopoietic (LH) cancers remains uncertain, particularly at low… Expand
An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure.
- D. Eastmond, M. Smith, R. Irons
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1 October 1987
Benzene-induced myelotoxicity can be reproduced by the coadministration of two principal metabolites, phenol and hydroquinone. Coadministration of phenol (75 mg/kg) and hydroquinone (25-75 mg/kg)… Expand
Peripheral blood effects in benzene-exposed workers.
- A. Robert Schnatter, P. J. Kerzic, +8 authors R. Irons
- Chemistry, Medicine
- Chemico-biological interactions
- 19 March 2010
The hematotoxic effects of benzene exposure may be important in the occurrence of subsequent health effects. We sought to provide further information on peripheral blood effects by studying 928… Expand
An essential role for NF-kappaB in human CD34(+) bone marrow cell survival.
- D. Pyatt, W. Stillman, Y. Yang, S. Gross, J. H. Zheng, R. Irons
- Medicine
- Blood
- 1999
The transcription factor, NF-kappaB, is important for T-cell activation, B-cell maturation, and human immunodeficiency virus transcription and plays a role in alternatively mediating and protecting… Expand
Analysis of hydroquinone and catechol in peripheral blood of benzene-exposed workers.
- P. J. Kerzic, W. S. Liu, +4 authors R. Irons
- Chemistry, Medicine
- Chemico-biological interactions
- 19 March 2010
We have developed a gas chromatography-mass spectrometry method for analysis of benzene (BZ) metabolites in human urine and blood. Here we describe peripheral blood concentrations of hydroquinone… Expand
Benzene disposition in the rat after exposure by inhalation.
- D. Rickert, T. S. Baker, J. Bus, C. Barrow, R. Irons
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1 July 1979
Abstract Little information is available on benzene disposition after exposure by inhalation despite the importance of this route in man. Benzene metabolites as a group have been measured in bone… Expand
Quinones as toxic metabolites of benzene.
- R. Irons
- Biology, Medicine
- Journal of toxicology and environmental health
- 1985
Occupational exposure to benzene has long been associated with toxicity to the blood and bone marrow, including lymphocytopenia, pancytopenia, aplastic anemia, acute myelogenous leukemia, and… Expand
Aggressive Natural Killer Cell Leukemia: Report of a Chinese Series and Review of the Literature
- J. Ryder, Xiaoqin Wang, L. Bao, S. Gross, Fu Hua, R. Irons
- Biology, Medicine
- International journal of hematology
- 2007
Aggressive natural killer cell leukemia (ANKL) is a rare Epstein-Barr virus (EBV)-associated fulminating disease that is widely disseminated at diagnosis. Because of its typically extranodal… Expand
A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China
The frequency of subtypes of lymphoid neoplasms was determined in a prospective series of 831 patients presenting at 29 Shanghai hospitals over a 4-year period. Diagnosis and classification was… Expand
Chronic exposure to benzene results in a unique form of dysplasia.
Hematotoxicity following chronic benzene exposure has been recognized for over a century, although the mechanism remains unknown. We describe a novel form of bone marrow dysplasia in 23 workers… Expand
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