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Guidelines for the diagnosis and management of adult aplastic anaemia
TLDR
The authors thank Sally B. Killick, Nick Bown, Jamie Cavenagh, Inderjeet Dokal, Theodora Foukaneli, Peter Hillmen, Robin Ireland, Austin Kulasekararaj, Ghulam Mufti, John A Snowden, Sujith Samarasinghe and Anna Wood for their help.
Identification and Characterization of thescl Gene Encoding a Group A StreptococcusExtracellular Protein Virulence Factor with Similarity to Human Collagen
TLDR
A new extracellular GAS virulence factor that is widely distributed in the species and participates in adherence to host cells and soft tissue pathology is identified.
Standardization of flow cytometry in myelodysplastic syndromes: report from the first European LeukemiaNet working conference on flow cytometry in myelodysplastic syndromes
TLDR
Despite strong evidence for an impact of FCM in myelodysplastic syndromes, further (prospective) validation of markers and immunophenotypic patterns are required against control patient groups as well as further standardization in multi-center studies.
Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane
TLDR
It is found that ubiquitination does not affect SopB stability or membrane association, or SopB‐dependent events in SCV biogenesis, however, two spatially and temporally distinct events are dependent on ubiquitinations.
Longitudinal analysis of the group A Streptococcus transcriptome in experimental pharyngitis in cynomolgus macaques.
TLDR
It was discovered that temporal changes in the GAS transcriptome were integrally linked to the phase of clinical disease and host-defense response, and this provides avenues for targeted investigation of proven and putative virulence factors and genes of unknown function.
Gonococcal opacity protein promotes bacterial entry-associated rearrangements of the epithelial cell actin cytoskeleton
TLDR
Results indicate that Opa-mediated gonococcal entry into Chang cells resembles phagocytosis rather than macropinocyTosis reported for Salmonella spp.
TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis
TLDR
Patients with mutant TP53 had a paucity of mutations in other genes implicated in myeloid malignancies, however clones increased in non‐responders and persisted at relapse, suggesting an early occurrence of TP53 mutations.
Characterization of an Extracellular Virulence FactorMade by Group A Streptococcus with Homology to theListeria monocytogenes Internalin Family ofProteins
TLDR
The first GAS LRR protein, designated Slr, is characterized as an extracellular virulence factor that contributes to pathogenesis and may participate in evasion of the innate host defense.
Standardization of flow cytometry in myelodysplastic syndromes: a report from an international consortium and the European LeukemiaNet Working Group
TLDR
The working group is dedicated to initiate further studies to establish robust diagnostic and prognostic FC panels in MDS and stresses that FC should be part of an integrated diagnosis rather than a separate technique.
Revisiting guidelines for integration of flow cytometry results in the WHO classification of myelodysplastic syndromes—proposal from the International/European LeukemiaNet Working Group for Flow
Definite progress has been made in the exploration of myelodysplastic syndromes (MDS) by flow cytometry (FCM) since the publication of the World Health Organization 2008 classification of myeloid
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