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Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture.
TLDR
The results indicate that the primary determinant of cell lethality in HT-29 cells is the degree of fluoropyrimidine substitution in nuclear RNA and not inhibition of either DNA or RNA synthesis. Expand
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
TLDR
3-deazaneplanocin may have therapeutic potential as an anticancer or antiviral drug and be competitive with the substrate adenosine. Expand
Cyclopentenyl cytidine analogue. An inhibitor of cytidine triphosphate synthesis in human colon carcinoma cells.
The mechanism of action of the cyclopentenyl analogue of cytidine, cCyd, was investigated in human colon carcinoma cell line HT-29. Upon exposure of cells to 10(-6)M cCyd, cell viability was reducedExpand
3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells.
TLDR
It is demonstrated that c3Nep is a potent inhibitor of AdoHcy synthesis with a low degree of cytotoxicity and rRNA and tRNA methylation was inhibited significantly by Nep, but c2Nep and c3Ari inhibited t RNA methylation but not rRNA methylations to a lesser degree. Expand
Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine.
TLDR
The results indicate that the reduction in CTP levels leads to rapid inhibition of DNA synthesis and reduction in c-myc mRNA levels which precede the appearance of differentiated cells. Expand
Effects of 8-azaadenosine and formycin on cell lethality and the synthesis and methylation of nucleic acids in human colon carcinoma cells in culture.
TLDR
The results suggest that the incorporation of formycin into nucleic acids, particularly DNA, correlates closely with its lethal effect on cell viability. Expand
9-Deazaadenosine. Cytocidal activity and effects on nucleic acids and protein synthesis in human colon carcinoma cells in culture.
TLDR
The results suggest that the rapidity by which cell lethality is produced by c9Ado may be related to inhibition of translation via its incorporation into RNA. Expand
Pharmacological studies of 3'-(4-morpholinyl)-3'-deaminodaunorubicin in human colon carcinoma cells in vitro.
TLDR
The strikingly different pharmacodynamic properties of these drugs related to the greater lipid solubility of MD versus ADR but not to their binding affinities to DNA, which were similar. Expand
In vitro translation of messenger RNA following exposure of human colon carcinoma cells in culture to 5-fluorouracil and 5-fluorouridine.
TLDR
Results suggest that drug-modified mRNA is probably not associated with the cytotoxicity manifested by these drugs and should not be associated with drug-induced cell lethality. Expand
1-beta-D-arabinosyl-5-azacytosine. Cytocidal activity and effects on the synthesis and methylation of DNA in human colon carcinoma cells.
TLDR
Data indicate that araAC appears to behave more as an analogue of araC rather than of dAZC or AZC, wherein it produces rapid inhibition of DNA synthesis and is incorporated into DNA. Expand
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