• Publications
  • Influence
Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans.
Human airways produce nitric oxide (NO), and exhaled NO increases as expiratory flow rates fall. We show that mixing during exhalation between the NO produced by the lower, alveolar airways (VL(NO))Expand
  • 153
  • 9
  • PDF
Evaluation of the forced oscillation technique for the determination of resistance to breathing.
Total respiratory resistance (R(T)) was measured by the application of a sine wave of airflow to the mouth at the resonant frequency of the respiratory system. The mean respiratory resistance of 42Expand
  • 105
  • 6
  • PDF
Pulmonary Function, Diffusing Capacity, and Inflammation in Healthy and Asthmatic Subjects Exposed to Ultrafine Particles
Particulate air pollution is associated with asthma exacerbations and increased morbidity and mortality from respiratory causes. Ultrafine particles (particles less than 0.1 μ m in diameter) mayExpand
  • 137
  • 6
  • PDF
Airway responses to sulfate and sulfuric acid aerosols in asthmatics. An exposure-response relationship.
Epidemiologic studies support an association between elevated levels of sulfates and increased symptoms in asthmatics. To determine if these pollutants produce airway responses, 17 asthmatics inhaledExpand
  • 107
  • 4
Lung tissue volume and blood flow by rebreathing theory.
Rebreathing determinations of pulmonary tissue volume (Vt) and pulmonary capillary blood flow (Qc) are supplanting breath-holding methods because of the shorter time for data collection and betterExpand
  • 88
  • 3
Determination of production of nitric oxide by lower airways of humans--theory.
Exercise and inflammatory lung disorders such as asthma and acute lung injury increase exhaled nitric oxide (NO). This finding is interpreted as a rise in production of NO by the lungs (VNO) butExpand
  • 113
  • 3
NHLBI workshop summary. Workshop on techniques to evaluate lung alveolar-microvascular injury.
  • 75
  • 2
Effect of the rebreathing pattern on pulmonary tissue volume and capillary blood flow.
Noninvasive rebreathing measurements of pulmonary tissue volume (Vt) and pulmonary capillary blood flow (Qc) theoretically and experimentally vary with the rebreathing maneuver. To determine theExpand
  • 20
  • 2
Serum alpha 1-antitrypsin variants. Prevalence and clinical spirometry.
  • 59
  • 1
Airway reactivity to sulfate and sulfuric acid aerosols in normal and asthmatic subjects.
Recent epidemiologic studies have emphasized a relationship between alteration in lung function, respiratory symptoms in asthmatics, and elevated levels of sulfate air pollutants. In asthmatics, itExpand
  • 59
  • 1