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Obesity, adipokines and asthma
Whether obesity is associated with asthma in three time points of life, and whether immunomodulatory adipokines, leptin and adiponectin are linked to overweight‐associated asthma is examined. Expand
Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans.
In conclusion, insulin-stimulated glucose uptake per kilogram fat is higher in visceral than in sc adipose tissue, which does not seem to contribute substantially to the reduced insulin stimulated whole-body glucose uptake in obesity. Expand
Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial.
A modified Mediterranean-type diet rich in omega-3 fatty acids efficiently potentiated the cholesterol-lowering effect of simvastatin, counteracted the fasting insulin-elevating effect of simulator, and did not decrease serum levels of beta-carotene and ubiquinol-10. Expand
Serum leptin concentrations in women with polycystic ovary syndrome.
The concept that circulating leptin levels would be different in PCOS patients than in regularly menstruating control subjects is not supported by the data. Expand
NSAID use and the risk of hospitalization for first myocardial infarction in the general population: a nationwide case-control study from Finland.
Current use of all NSAIDs is associated with a modest risk of first time MI, and all durations from 1 to 180 days of conventional NSAIDs and from 31 to 90 days duration of COX-2 selective NSAIDs were associated with an elevated risk of MI. Expand
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptinExpand
Inverse correlation between serum testosterone and leptin in men.
It is concluded that testosterone has a suppressive effect on leptin production, as reflected by circulating levels of this hormone in elderly men. Expand
Anticholinergic Drug Use, Serum Anticholinergic Activity, and Adverse Drug Events Among Older People: A Population-Based Study
This finding supports the usefulness of these lists to help identify patients at risk of anticholinergic ADEs in clinical practice. Expand
Human adipose tissue glucose uptake determined using [18F]-fluoro-deoxy-glucose ([18F]FDG) and PET in combination with microdialysis
[18F]FDG-PET seems a feasible tool to investigate adipose tissue glucose metabolism in human beings and the LC does not appear to be altered in insulin resistance, which is similar in the obese and the non-obese subjects. Expand
The association between obesity and the prevalence of low back pain in young adults: the Cardiovascular Risk in Young Finns Study.
The authors' findings in a relatively young population suggest that abdominal obesity may increase the risk of LBP in women, independent of C-reactive protein, leptin, and adiponectin levels. Expand