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The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
  • J. Damen, L. Liu, +4 authors G. Krystal
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 20 February 1996
A 145-kDa tyrosine-phosphorylated protein that becomes associated with Shc in response to multiple cytokines has been purified from the murine hemopoietic cell line B6SUtA1 and is suggested to be called SHIP for SH2-containing inositol phosphatase, based on its properties. Expand
Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span.
It is shown that although SHIP null mice are viable and fertile, they fail to thrive and survival is only 40% by 14 weeks of age, and homozygous disruption of SHIP establishes the crucial role of this molecule in modulating cytokine signaling within the hemopoietic system. Expand
The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
Mouse haematopoietic stem cells (HSCs) undergo a postnatal transition in several properties, including a marked reduction in their self-renewal activity. We now show that the developmentally timedExpand
Hox genes in hematopoiesis and leukemogenesis
It is proposed that Hox-dependent pathways are closely linked to the self-renewal program crucial to the origin and function of leukemic stem cells. Expand
Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells.
The expression of a broad range of Hox genes in primitive hematopoietic cells are demonstrated and point to the existence of a regulated program of H Cox gene expression during their normal development. Expand
Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines.
Both multipotential and committed basophil/mast cell lines demonstrated absolute dependence upon a source of a growth factor(s) found in medium conditioned by WEHI-3 cells. Expand
Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.
Investigation of this assay system has shown that all three potential sources of stem cells can under appropriate circumstances contribute to long-term hematopoietic regeneration, thus establishing both the competitive pressure of hematoplastic stem cells in the cotransplanted compromised population and in the host, and the need to use genetic markers to track the specific contribution of the injected test cells. Expand
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product
It is shown that signaling via the SLAM-SAP pathway in an established T cell line can alter the profile of cytokine production during T cell activation, and a mechanism by which a putative adaptor molecule is required for receptor-mediated signaling events in the immune system is identified. Expand
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts
The hematopoietic-restricted protein Src homology 2–containing inositol-5-phosphatase negatively regulates osteoclast formation and function and the absence of this enzyme results in severe osteoporosis. Expand
Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy
In two mouse SCD models, Berkeley and SAD, inhibition of red blood cell dehydration and sickling was achieved with correction of hematological parameters, splenomegaly, and prevention of the characteristic urine concentration defect. Expand