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CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
ABSTRACTGenome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including… Expand
Associations between Urinary Excretion of Cadmium and Renal Biomarkers in Nonsmoking Females: A Cross-Sectional Study in Rural Areas of South China
- Yun-rui Zhang, Ping Wang, +11 authors Y. Wu
- International journal of environmental research…
- 24 September 2015
Objectives: The aim of this study was to systematically evaluate the relationship between urinary excretion of cadmium (U-Cd) and biomarkers of renal dysfunction. Methods: One hundred eighty five… Expand
Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia
BackgroundHigh-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but the exact mechanisms… Expand
Effect of Ginkgo biloba on visual field and contrast sensitivity in Chinese patients with normal tension glaucoma: a randomized, crossover clinical trial.
- X. Guo, Xiangbin Kong, +6 authors N. Congdon
- Investigative ophthalmology & visual science
- 7 January 2014
PURPOSE We evaluated the effect of ginkgo biloba extract on visual field defect and contrast sensitivity in a Chinese cohort with normal tension glaucoma. METHODS In this prospective, randomized,… Expand
Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway.
- K. Kang, Y. Gao, +11 authors K. Yu
- Biomedicine & pharmacotherapy = Biomedecine…
- 1 October 2018
Acute kidney injury (AKI) is a clinical syndrome that results in severe tubular damage with high morbidity and mortality. However, there is a lack of effective therapy strategies. Therefore, it is… Expand
SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497
- Q. Ding, K. He, +14 authors Guoan Xiang
- Biology, Medicine
- Molecular therapy : the journal of the American…
- 12 January 2016
The aim of this study is to clarify the clinical implication and functional role of structure specific recognition protein 1 (SSRP1) in hepatocellular carcinoma (HCC) and explore the underlying… Expand
Colorectal cancer stem cell and chemoresistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor
Colorectal cancer stem cells (Co-CSCs) are a small subpopulation of tumor cells which have been proposed to be tumor-initiating cells in colorectal cancer (CRC) and to be implicated in resistance to… Expand
Comparison of presentation and clinical outcome between children and young adults with differentiated thyroid cancer.
BACKGROUND The aim of the present study was to evaluate the presentation, clinical course and outcome between children and young adults with differentiated thyroid cancer (DTC) treated in our… Expand
MicroRNA-93 suppress colorectal cancer development via Wnt/β-catenin pathway downregulating
MicroRNA-93 (miR-93) is involved in several carcinoma progressions. It has been reported that miR-93 acts as a promoter or suppressor in different tumors. However, till now, the role of miR-93 in… Expand
Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1.
The development of acute lung injury (ALI) during sepsis almost doubles the mortality rate of patients. The efficacy of current treatment strategies is low as treatment is usually initiated following… Expand