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Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron.
- T. Šimůnek, M. Štěrba, O. Popelová, M. Adamcová, R. Hrdina, V. Geršl
- Chemistry, MedicinePharmacological reports : PR
Several lines of evidence suggest that mechanisms other than the traditionally emphasized "ROS and iron" hypothesis are involved in anthracycline-induced cardiotoxicity and that these alternative mechanisms may be better bases for designing approaches to achieve efficient and safe cardioprotection.
- R. Hrdina, V. Geršl, Ivona Klimtová, T. Šimůnek, Jarmila Machácková, M. Adamcová
- Chemistry, MedicineActa medica
Modification of dosage schedule and synthesis of new anthracycline analogues may represent alternative approaches to mitigate anthrACYcline cardiotoxicity while preserving antitumour activity.
In vitro analysis of iron chelating activity of flavonoids.
- P. Mladěnka, K. Macáková, +6 authors L. Saso
- Chemistry, MedicineJournal of inorganic biochemistry
- 1 May 2011
It is demonstrated that the most effective iron binding site of flavonoids represents 6,7-dihydroxy structure, which is incorporated in baicalein structure which formed, similarly to deferoxamine, the complexes with iron in the stoichiometry 1:1 and was not inferior in all tested pH to deferredoxamine.
Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity.
- P. Mladěnka, L. Zatloukalová, T. Filipský, R. Hrdina
- Chemistry, MedicineFree radical biology & medicine
- 15 September 2010
This review shows that positive cardiovascular effects of flavonoid are achieved by various flavonoids via the interaction with different targets, including direct inhibition of some radical-forming enzymes, decreased platelet aggregation and leukocyte adhesion, and vasodilatory properties.
SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death.
- T. Šimůnek, C. Boer, +9 authors R. Musters
- Chemistry, MedicineJournal of molecular and cellular cardiology
- 1 August 2005
Iron chelation is presented as a very powerful tool by which oxidative stress-induced myocardial damage can be prevented.
In vitro evaluation of copper-chelating properties of flavonoids
Copper is an essential trace element involved in plenty of redox reactions in living systems, however, unbound copper ions cause damage to various biomolecules via excessive generation of reactive…
Iron reduction potentiates hydroxyl radical formation only in flavonols.
A substantial ferric ions reduction was achieved under acidic conditions, particularly by flavonols and flavanols with the catecholic ring B, while 7-hydroxyflavone and hesperetin were the only flavonoids with dose-dependent inhibition of hydroxyl radical production.
In vitro interactions of coumarins with iron.
Conclusively, the use of iron-chelating coumarins in acidic conditions may be disadvantageous in contrast to neutral conditions.
The role of reactive oxygen and nitrogen species in cellular iron metabolism
- P. Mladěnka, T. Šimůnek, Mojmír Hübl, R. Hrdina
- Chemistry, MedicineFree radical research
- 1 January 2006
It is suggested that reactive oxygen and nitrogen species can significantly affect iron metabolism and their interaction with iron-regulatory proteins (IRPs) seems to be one of the essential mechanisms of influencing iron homeostasis.
Rabbit model for in vivo study of anthracycline‐induced heart failure and for the evaluation of protective agents
- T. Šimůnek, Ivona Klimtová, +5 authors V. Geršl
- MedicineEuropean journal of heart failure
- 1 June 2004
Cardiac toxicity associated with chronic administration of anthracycline (ANT) antibiotics represents a serious complication of their use in anticancer chemotherapy, but can also serve as a useful…