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Chromatographic demonstration of reversible changes in endothelial permeability.
This report describes a new in vitro method for measuring the diffusional permeability of an endothelial monolayer and its use in investigating the modulation of permeability by various agents, e.g.,Expand
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Pulmonary antiallergic and bronchodilator effects of isozyme-selective phosphodiesterase inhibitors in guinea pigs.
The effectiveness of theophylline (aminophylline) in treating asthma may result in part from nonselective inhibition of multiple isozymes of cyclic nucleotide phosphodiesterase (PDE). The roles forExpand
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Characterization of beta-adrenergic receptors in cultured human and bovine endothelial cells.
We used radioligand binding methods to characterize beta-adrenergic receptors on endothelial cells cultured from adult human iliac vein (HIVE) and bovine fetal aorta (BFAE). For comparison, we alsoExpand
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Inhibition of antigen-induced pulmonary eosinophilia and neutrophilia by selective inhibitors of phosphodiesterase types 3 or 4 in Brown Norway rats.
Rolipram, a phosphodiesterase type 4 (PDE4)-selective inhibitor, has been demonstrated to inhibit antigen-induced pulmonary eosinophilia in guinea pigs and monkeys, suggesting that PDE4-selectiveExpand
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Characterization of the airway smooth muscle muscarinic receptor in vivo.
We examined the bronchodilator activity of eight subtype-selective and non-selective muscarinic antagonists in anesthetized, ventilated guinea pigs bronchoconstricted by carbachol aerosols. RelativeExpand
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Artery ligation in bleeding cervical cancer.
Abstract A method of attacking carcinoma of the cervix by severing the nutritional supply line and at the same time stopping or markedly reducing the amount of bleeding is presented. The advantagesExpand
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Analysis of rabbit pulmonary angiotensin converting enzyme kinetics in vivo.
We investigated the kinetics of pulmonary angiotensin converting enzyme (ACE) in vivo by measuring the hydrolysis of a bolus dose of a synthetic ACE substrate, benzoyl-phenylalanyl-alanyl-prolineExpand
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Inhibition of lipopolysaccharide-induced pulmonary edema by isozyme-selective phosphodiesterase inhibitors in guinea pigs.
There is a need for pharmacological agents for the treatment of pulmonary edema associated with the adult respiratory distress syndrome. Therefore, we examined the effects of isozyme-selective cyclicExpand
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Kinetics of captopril- and enalapril-induced inhibition of pulmonary angiotensin converting enzyme in vivo.
The kinetics of angiotensin converting enzyme (ACE) inhibition by captopril (SQ 14225) and enalapril (MK 421) in anesthetized rabbits was investigated. Kinetic parameters, apparent Km, an index ofExpand
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Multiple mechanisms of xanthine actions on airway reactivity.
  • R. Howell
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 December 1990
Xanthines are effective in the treatment of asthma, but the mechanism of action remains unclear. Pulmonary effects of seven xanthines, exhibiting a range of potencies as cyclic nucleotideExpand
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