Regulation of Mammary Gland Growth and Morphogenesis by the Mammary Fat Pad: A Species Comparison
Differences between the morphological development of the mammary parenchyma in rodents, humans, and ruminant dairy animals are highlighted, placing emphasis on differences in the cellular composition and structure of the Mammary fat pad.
Establishing a Framework for the Functional Mammary Gland: From Endocrinology to Morphology
Defining the hormonal control of ductal development should facilitate a better understanding of the mechanisms underlying mammary gland tumorigenesis and provide the opportunity to further delineate the regulation ofductal development.
Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein.
- J. Trott, R. Hovey, S. Koduri, B. Vonderhaar
- Biology, MedicineJournal of Molecular Endocrinology
- 1 February 2003
Data indicate the presence of multiple isoforms of the hPRLR that may function to modulate the endocrine and autocrine effects of PRL in normal human tissue and cancer.
Comparison of five different RNA sources to examine the lactating bovine mammary gland transcriptome using RNA-Sequencing
The results indicate that the SC and MFG transcriptome are representative of MGT and LCMEC and can be used as effective and alternative samples to study mammary gland expression without the need to perform a tissue biopsy.
Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function
This article focuses on adipocytes as local regulators of epithelial cell growth and their function during lactation and suggests that adipocytes within the mammary fat pad may function differently from those in other fat depots.
Transcriptional regulation of vascular endothelial growth factor expression in epithelial and stromal cells during mouse mammary gland development.
Results support the conclusion that VEGF is differentially transcribed by specific cell types within the mammary gland, and that under hormonal regulation it functions in an autocrine/paracrine manner.
Growth and development of the mammary glands of livestock: a veritable barnyard of opportunities.
Sequencing the transcriptome of milk production: milk trumps mammary tissue
RNA extracted from the milk fat during lactation accurately portrayed the RNA profile of milk-producing mammary epithelial cells in a non-human primate, however, this sample type clearly requires protocols that minimize RNA degradation.
C/EBPβ (CCAAT/Enhancer Binding Protein) Controls Cell Fate Determination during Mammary Gland Development
The data suggest that C/EBPbeta may control cell fate decisions in the mammary gland through the appropriate temporal and spatial expression of molecular markers, such as PR, that induce the proliferation of alveolar progenitor cells via juxtacrine mechanisms.
Lactation and Neonatal Nutrition: Defining and Refining the Critical Questions
- M. Neville, S. M. Anderson, P. Williamson
- MedicineJournal of mammary gland biology and neoplasia
- 1 July 2012
A roadmap for multidisciplinary research into all aspects of human lactation, milk and its role in infant nutrition for the next decade and beyond is presented.