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Sirtuins as regulators of metabolism and healthspan
- R. Houtkooper, E. Pirinen, J. Auwerx
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 7 March 2012
Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in… Expand
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11… Expand
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
SIRT1 regulates energy homeostasis by controlling the acetylation status and activity of a number of enzymes and transcriptional regulators. The fact that NAD(+) levels control SIRT1 activity confers… Expand
Mitonuclear protein imbalance as a conserved longevity mechanism
Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial… Expand
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
As NAD(+) is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line with this… Expand
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.
A century after the identification of a coenzymatic activity for NAD(+), NAD(+) metabolism has come into the spotlight again due to the potential therapeutic relevance of a set of enzymes whose… Expand
The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling
NAD(+) is an important cofactor regulating metabolic homeostasis and a rate-limiting substrate for sirtuin deacylases. We show that NAD(+) levels are reduced in aged mice and Caenorhabditis elegans… Expand
The metabolic footprint of aging in mice
Aging is characterized by a general decline in cellular function, which ultimately will affect whole body homeostasis. Although DNA damage and oxidative stress all contribute to aging, metabolic… Expand
Cardiolipin, the heart of mitochondrial metabolism
Abstract.Cardiolipin is a unique phospholipid, which is almost exclusively localized in the mitochondrial inner membrane where it is synthesized from phosphatidylglycerol and… Expand
Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome*
- Devrim Acehan, F. Vaz, +8 authors Z. Khuchua
- Biology, Psychology
- The Journal of Biological Chemistry
- 9 November 2010
Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue, delayed growth, and… Expand