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Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain
TLDR
The results suggest that only the free (unbound) fraction of methadone present in blood is extracted by the liver and that methdone can be classified as a low (hepatic)‐extraction drug.
The memorial pain assessment card. A valid instrument for the evaluation of cancer pain
TLDR
The Memorial Pain Assessment Card can distinguish pain intensity from pain relief and from general psychological distress, and it can provide multidimensional assessment that is practically equivalent to the full assessment battery.
The Pharmacokinetics of Heroin in Patients with Chronic Pain
TLDR
It is concluded that heroin is a pro-drug that serves to determine the distribution of its active metabolites and that oral heroin is converted to morphine and appears to be an inefficient means of providing morphine to the systemic circulation.
Sublingual absorption of selected opioid analgesics
TLDR
The results indicate that although the sublingual absorption and apparent sublingUAL bioavailability of morphine are poor, the sublingsual absorption of methadone, fentanyl, and buprenorphine under controlled conditions is relatively high.
Benzydamine HCl, A New Agent for the Treatment of Radiation Mucositis of the Oropharynx
TLDR
Analysis of the data showed that benzydamine HC1 used as a rinse/gargle provided a statistically significant and clinically meaningful alleviation of the symptoms of oropharyngeal mucositis, and there was also significant improvement in terms of reduction in hyperemia and mucosit is in benzydamines group.
Treatment of opioid-induced constipation with oral naloxone: a pilot study.
TLDR
Oral naloxone ameliorates opioid-induced constipation in opioid-dependent persons and Titration of dose to a maximum of 12 mg at least 6 hours apart may be needed to avoid adverse reactions.
The effects of morphine methadone and meperidine on some reflex responses of spinal animals to nociceptive stimulation.
TLDR
A method was suggested whereby predetermination of this physical limitation of the D9Amour-Smith technique may be utilized to define a uniform "maximal measurable effect" ceiling for any given intensity of stimulus used.
A dinical eomparison of the analgesie effects of methadone and morphine administered intramuseularly, and oforally and parenterally administered methadone
TLDR
The relative analgesic potency of single graded intramuscular doses of methadone and morphine was evaluated in a double‐blind crossover study in patients with chronic pain due to cancer and methamphetamineadone was found to be approximately one half as potent orally as it was parenterally.
Analgesic studies of codeine and oxycodone in patients with cancer. II. Comparisons of intramuscular oxycodone with intramuscular morphine and codeine.
TLDR
The results of these studies do not appear to support the hypothesis that, in man, the analgesic activity of codeine is due to its O-demethylation to morphine, and demonstrate a highly consistent pattern of analgesic structure-activity relationships encompassing morphine, oxymorphone, codeine and oxycodone.
Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer.
TLDR
Data indicate that normeperidine can contribute to the excitatory effects seen after multiple doses of meperidine and suggest that patients with renal failure are particularly susceptible to this problem.
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