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Improved 3D triple resonance experiments, HNN and HN(C)N, for HN and 15N sequential correlations in (13C, 15N) labeled proteins: Application to unfolded proteins
Two triple resonance experiments, HNN and HN(C)N, are presented which correlate HN and 15N resonances sequentially along the polypeptide chain of a doubly (13C, 15N) labeled protein. These…
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NMR studies on truncated sequences of human telomeric DNA: observation of a novel A-tetrad.
TLDR
NMR structural studies on two truncated human telomeric DNA sequences, d-AG( 3)T and d-TAG(3)T in solutions containing K(+)ions are described and are expected to be significant from the point of view of structural diversity and recognition in telomeres.
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NMR observation of T-tetrads in a parallel stranded DNA quadruplex formed by Saccharomyces cerevisiae telomere repeats.
TLDR
The NMR structure of the DNA sequence d-TGGTGGC containing two repeats of Saccharomyces cerevisiae telomere DNA, a novel quadruplex incor-porating T-tetrads formed by symmetrical pairing of four Ts via O4-H3 H-bonds in a plane is reported.
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NMR observation of a novel C-tetrad in the structure of the SV40 repeat sequence GGGCGG.
TLDR
To the authors' knowledge this is the first report of C-tetrad formation in DNA structures, and would be of significance from the point of view of both structural diversity and specific recognition.
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NMR characterization of the energy landscape of SUMO-1 in the native-state ensemble.
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Recognition schemes for protein-nucleic acid interactions
TLDR
The studies indicate that the conformation of this DNA fragment is predominantly B-type except near the binding sites where the ribose ring prefers a3E conformation, which raises the general question about the presence of specificity in the inherent backbone structures of proteins and nucleic acids as opposed to specific intermolecular interactions.
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Molecular conformation of gonadoliberin using two-dimensional NMR spectroscopy.
TLDR
It has been inferred that the molecule possesses no short-range or long-range order under any of the three solvent conditions, however, there is a nonspecific increase in the linewidths when gonadoliberin is bound to model membranes, indicating a reduced internal motion in the molecule due to lipid-peptide interactions.
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Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma
TLDR
It is shown that single-stranded DNA modeled from the template strand of the BCL2 MBR, forms secondary structures that migrate faster on native PAGE in the presence of potassium, due to the formation of intramolecular G-quadruplexes.
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Dynamin Interacts with Members of the Sumoylation Machinery*
TLDR
The results suggest that the coiled-coil GTPase effector domain (GED) of dynamin may serve as a scaffold that concentrates the sumoylation machinery in the vicinity of potential acceptor proteins.
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NMR structure of a 2',5' RNA favors A type duplex with compact C2'endo nucleotide repeat.
TLDR
A high resolution NMR structure of a 2',5' RNA fragment r(GCCGCGGC) forms an A type duplex with C2'endo compact nucleotide repeat, instead of the familiar C3'endo Compact nucleotide (seen in RNA) supporting the deductions made earlier from stereochemical considerations.
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