Physiology of status epilepticus in primates.
- B. Meldrum, R. Horton
- MedicineArchives of Neurology
- 1973
In adolescent baboons the intravenous injection of bicuculline induced generalized seizures lasting up to five hours, which sometimes led to brain damage or death, and a behavioral and electroencephalographic recovery could occur within three hours of generalized seizure activity lasting one to two hours.
5-HT1A receptor binding sites in post-mortem brain samples from depressed suicides and controls.
- S. Lowther, F. de Paermentier, S. Cheetham, M. Crompton, C. Katona, R. Horton
- Psychology, BiologyJournal of Affective Disorders
- 1 February 1997
ENZYMIC AND CEREBRAL METABOLIC EFFECTS OF 2‐DEOXY‐d‐GLUCOSE
- R. Horton, B. Meldrum, H. Bachelard
- Chemistry, BiologyJournal of Neurochemistry
- 1 September 1973
Analysis of the fate of d‐[U‐14C] glucose given subcutaneously 5 min before death showed that glucose uptake was reduced, however brain glucose concentration rose three to five‐fold 20–30 min after 2‐deoxy‐d‐glucose, and the majority of glucose entering the brain after 10 min of 2‐ deoxy‐ d‐glUCose treatment was recovered as glucose.
Species differences in brain adenosine A1 receptor pharmacology revealed by use of xanthine and pyrazolopyridine based antagonists
- Takuya Maemoto, Keith Finlayson, Henry J. Olverman, Atsushi Akahane, R. Horton, S. Butcher
- Biology, ChemistryBritish Journal of Pharmacology
- 1 November 1997
Three novel pyrazolopyridine derivatives represent high affinity, adenosine A1 receptor selective drugs that, in contrast to xanthine based antagonists, exhibit similar affinity for [3H]‐DPCPX binding sites in human, rat, mouse and guinea‐pig membranes.
Brain 5-HT2 receptor binding sites in depressed suicide victims
- S. Cheetham, M. Crompton, C. Katona, R. Horton
- Psychology, BiologyBrain Research
- 8 March 1988
Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides
- K. Lawrence, F. D. Paermentier, S. Cheetham, M. Crompton, C. Katona, R. Horton
- Psychology, MedicineBrain Research
- 27 August 1990
Seizures induced by allylglycine, 3‐mercaptopropionic acid and 4‐deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase
- R. Horton, B. Meldrum
- Biology, ChemistryBritish Journal of Pharmacology
- 1 September 1973
Inhibition of GAD activity was evident 30–60 min before seizure onset following allylglycine or 4‐deoxypyridoxine administration, and was maximal just before or during seizure activity.
Photically induced epilepsy in Papio papio as a model for drug studies.
- B. Meldrum, G. Anlezark, E. Balzamo, R. Horton, M. Trimble
- Psychology, MedicineAdvances in neurology
- 1975
A modification of the natural model (using allylglycine as a priming agent) is convenient for correlating acute anticonvulsant activity and neurological toxicity with plasma concentrations of anticonVulsant agents.
Carbon monoxide poisoning
- S. Cheetham, R. Horton, M. Crompton, C. Katona
- Medicine
- 12 March 1988
Allopurinol may be a simple and effective treatment in the prevention of severe neuropsychiatric complications of carbon monoxide poisoning in combination with hyperbaric oxygen or with high concentrations of inspired oxygen at normal pressures.
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