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Prostaglandins: modulators of renal function and pressor resistance in chronic liver disease.
It is concluded that prostaglandins play a supportive role in maintaining renal function and are involved in the hyperreninism and pressor resistance of patients with liver disease. Expand
The source of plasma dihydrotestosterone in man.
  • T. Ito, R. Horton
  • Chemistry, Medicine
  • The Journal of clinical investigation
  • 1 August 1971
It is suggested that dihydrotestosterone in the blood does not arise from direct secretion but may reflect events occurring in peripheral androgen target tissues. Expand
Hyperreninemic hypoaldosteronism in the critically ill: a new entity.
Selective hypoaldosteronism in the presence of high renin levels exists in a substantial percentage of hypotensive critically ill patients, suggesting that the defect was probably at the level of the zone glomerulosa cell. Expand
Dihydrotestosterone is a peripheral paracrine hormone.
  • R. Horton
  • Biology, Medicine
  • Journal of andrology
  • 2 January 1992
3 alpha androstanediol glucuronide appears to be the best marker available of DHT formation in target tissues such as skin, and is a good marker of response to therapy in adrenal disorders of androgenicity such as andrenogenital syndrome. Expand
Conversion of blood androgens to estrogens in normal adult men and women.
Whether measured as conversion ratio or transfer constant, the peripheral aromatization of androstenedione takes place to a greater degree than that of testosterone, and, for the respective androgens, both the conversion ratio and [rho](BB) value are greater in males than females. Expand
Effect of aldosterone on the metabolism of magnesium.
  • R. Horton, E. Biglieri
  • Chemistry, Medicine
  • The Journal of clinical endocrinology and…
  • 1 December 1962
It is suggested that aldosterone increases the clearance and excretion of magnesium and potassium in a parallel manner in patients with primary aldosteronism and in an adrenalectomized subject. Expand
Studies on the origin of androstanediol and androstanediol glucuronide in young and elderly men.
A major reduction in the plasma concentration of 3 alpha diol glucuronide occurs in the aging male, although no difference is seen in the levels of the unconjugated 3alpha diol. Expand
Peripheral androgens and the role of androstanediol glucuronide.
The feedback control of luteinizing hormone in normal adult men.
ABSTRACT The effect of “low” and “high” constant infusion doses for 48 hr of testosterone (T), estradiol (E2), dihydrotestosterone (DHT), and 17α-hydroxyprogesterone (17-OHP) were studied in 13Expand