R. Horobin

Publications227
h-index30
Citations3,812
Highly Influential Citations94
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A predictive model for the selective accumulation of chemicals in tumor cells
Cationic lipophilic dyes can accumulate in mitochondria, and especially in mitochondria of tumor cells. We investigated the chemical properties and the processes allowing selective uptake into tumor… Expand
  • 142
  • 13
MTT assay for cell viability: Intracellular localization of the formazan product is in lipid droplets.
Although MTT is widely used to assess cytotoxicity and cell viability, the precise localization of its reduced formazan product is still unclear. In the present study the localization of MTT formazan… Expand
  • 378
  • 10
Conn's biological stains : a handbook of dyes, stains and fluorochromes for use in biology and medicine
  • 151
  • 8
Quantitative modeling of selective lysosomal targeting for drug design
Lysosomes are acidic organelles and are involved in various diseases, the most prominent is malaria. Accumulation of molecules in the cell by diffusion from the external solution into cytosol,… Expand
  • 103
  • 7
  • PDF
Conn's Biological Stains
  • R. Horobin
  • Chemistry
  • The Histochemical Journal
  • 1 September 1970
  • 167
  • 5
Factors affecting the selection and use of tetrazolium salts as cytochemical indicators of microbial viability and activity.
The reduction of four tetrazolium cations (TCs), nitroblue tetrazolium (NBT), neotetrazolium (NT), methylthiazolyldiphenyltetrazolium (MTT) and iodonitrophenyltetrazolium (INT), by viable… Expand
  • 117
  • 3
Predicting the behaviour and selectivity of fluorescent probes for lysosomes and related structures by means of structure-activity models
SummaryCultured rat fibroblasts were exposed to 50 fluorescent probes of varied physicochemical characteristics. Probe concentrations, fluorochrome excitation wavelength and period of illumination,… Expand
  • 85
  • 3
Lipid domains of mycobacteria studied with fluorescent molecular probes
The complex mycobacterial cell envelope is recognized as a critical factor in our failure to control tuberculosis, leprosy and other non‐tuberculous pathogens. Although its composition has been… Expand
  • 117
  • 2
Fluorescent cationic probes for nuclei of living cells: why are they selective? A quantitative structure–activity relations analysis
Selectivity of nuclear probes is controlled by competitive accumulation of the probe by cellular organelles as well as the high affinity for nucleic acids. Physicochemical features of probes which… Expand
  • 84
  • 2
Apoptosis induction by different pathways with methylene blue derivative and light from mitochondrial sites in V79 cells
The importance of mitochondria for the induction of apoptosis by photodynamic therapy (PDT) was studied with a new photosensitizing dye, methylene blue derivative (MBD), and light. By using… Expand
  • 66
  • 2